Sa et al. identified a distinct neuronal subpopulation that controls brown adipose tissue thermogenesis. In mice fed a high-fat diet, hypothalamic GABRA5 neurons are deactivated by GABA released by surrounding astrocytes and inhibition of GABA synthesis ameliorates diet-induced obesity.
FörderungenEuropean Research Council (ERC) Ministerio de Ciencia e Innovacion of Spain Helmholtz Association - Initiative and Networking Fund German Research Foundation (DFG)