Sa et al. identified a distinct neuronal subpopulation that controls brown adipose tissue thermogenesis. In mice fed a high-fat diet, hypothalamic GABRA5 neurons are deactivated by GABA released by surrounding astrocytes and inhibition of GABA synthesis ameliorates diet-induced obesity.
POF Topic(s)90000 - German Center for Diabetes Research
Forschungsfeld(er)Helmholtz Diabetes Center
PSP-Element(e)G-501900-224
FörderungenEuropean Research Council (ERC) Ministerio de Ciencia e Innovacion of Spain Helmholtz Association - Initiative and Networking Fund German Research Foundation (DFG)