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Astrocytic GABA in LHA is an obesity ‘thermostat’.
Nat. Metab. 5, 1454-1455 (2023)
Sa et al. identified a distinct neuronal subpopulation that controls brown adipose tissue thermogenesis. In mice fed a high-fat diet, hypothalamic GABRA5 neurons are deactivated by GABA released by surrounding astrocytes and inhibition of GABA synthesis ameliorates diet-induced obesity.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Editorial
Schlagwörter
Lateral Hypothalamus
ISSN (print) / ISBN
2522-5812
e-ISSN
2522-5812
Zeitschrift
Nature metabolism
Quellenangaben
Band: 5,
Heft: 9,
Seiten: 1454-1455
Verlag
Springer
Verlagsort
London
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes and Obesity (IDO)
Förderungen
European Research Council (ERC)
Ministerio de Ciencia e Innovacion of Spain
Helmholtz Association - Initiative and Networking Fund
German Research Foundation (DFG)
Ministerio de Ciencia e Innovacion of Spain
Helmholtz Association - Initiative and Networking Fund
German Research Foundation (DFG)