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Chu, X.* ; Xiong, Y.* ; Knoedler, S. ; Lu, L.* ; Panayi, A.C.* ; Alfertshofer, M.* ; Jiang, D. ; Rinkevich, Y. ; Lin, Z.* ; Zhao, Z.* ; Guandong, L.* ; Bobin, M.* ; Guohui, L.*

Immunomodulatory nanosystems: Advanced delivery tools for treating chronic wounds.

Research 6:0198 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The increasingly aging society led to a rise in the prevalence of chronic wounds (CWs), posing a significant burden to public health on a global scale. One of the key features of CWs is the presence of a maladjusted immune microenvironment characterized by persistent and excessive (hyper)inflammation. A variety of immunomodulatory therapies have been proposed to address this condition. Yet, to date, current delivery systems for immunomodulatory therapy remain inadequate and lack efficiency. This highlights the need for new therapeutic delivery systems, such as nanosystems, to manage the pathological inflammatory imbalance and, ultimately, improve the treatment outcomes of CWs. While a plethora of immunomodulatory nanosystems modifying the immune microenvironment of CWs have shown promising therapeutic effects, the literature on the intersection of immunomodulatory nanosystems and CWs remains relatively scarce. Therefore, this review aims to provide a comprehensive overview of the pathogenesis and characteristics of the immune microenvironment in CWs, discuss important advancements in our understanding of CW healing, and delineate the versatility and applicability of immunomodulatory nanosystems-based therapies in the therapeutic management of CWs. In addition, we herein also shed light on the main challenges and future perspectives in this rapidly evolving research field.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Delta T-cells; Tissue-repair; Macrophage Polarization; Silver Nanoparticles; Oxidative Stress; Stem-cells; Skin; Inflammation; Hydrogel; System
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2639-5274
e-ISSN 2639-5274
Zeitschrift Research
Quellenangaben Band: 6, Heft: , Seiten: , Artikelnummer: 0198 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology and Medicine (IRBM)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-509400-001
Förderungen European Foundation for the Study of Diabetes (EFSD) Anniversary Fund Programme
LEO Foundation
European Research Council Consolidator Grant
China Postdoctoral Science Foundation
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration
National Science Foundation of China
DOI 10.34133/research.0198
WOS ID 001121336200001
Scopus ID 85166630265
PubMed ID 37456931
Erfassungsdatum 2023-12-06
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