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Immunomodulatory nanosystems: Advanced delivery tools for treating chronic wounds.
Research 6:0198 (2023)
The increasingly aging society led to a rise in the prevalence of chronic wounds (CWs), posing a significant burden to public health on a global scale. One of the key features of CWs is the presence of a maladjusted immune microenvironment characterized by persistent and excessive (hyper)inflammation. A variety of immunomodulatory therapies have been proposed to address this condition. Yet, to date, current delivery systems for immunomodulatory therapy remain inadequate and lack efficiency. This highlights the need for new therapeutic delivery systems, such as nanosystems, to manage the pathological inflammatory imbalance and, ultimately, improve the treatment outcomes of CWs. While a plethora of immunomodulatory nanosystems modifying the immune microenvironment of CWs have shown promising therapeutic effects, the literature on the intersection of immunomodulatory nanosystems and CWs remains relatively scarce. Therefore, this review aims to provide a comprehensive overview of the pathogenesis and characteristics of the immune microenvironment in CWs, discuss important advancements in our understanding of CW healing, and delineate the versatility and applicability of immunomodulatory nanosystems-based therapies in the therapeutic management of CWs. In addition, we herein also shed light on the main challenges and future perspectives in this rapidly evolving research field.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Delta T-cells; Tissue-repair; Macrophage Polarization; Silver Nanoparticles; Oxidative Stress; Stem-cells; Skin; Inflammation; Hydrogel; System
ISSN (print) / ISBN
2639-5274
e-ISSN
2639-5274
Zeitschrift
Research
Quellenangaben
Band: 6,
Artikelnummer: 0198
Verlag
American Association for the Advancement of Science (AAAS)
Verlagsort
1200 New York Ave, Nw, Washington, Dc 20005 Usa
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Regenerative Biology and Medicine (IRBM)
Förderungen
European Foundation for the Study of Diabetes (EFSD) Anniversary Fund Programme
LEO Foundation
European Research Council Consolidator Grant
China Postdoctoral Science Foundation
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration
National Science Foundation of China
LEO Foundation
European Research Council Consolidator Grant
China Postdoctoral Science Foundation
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration
National Science Foundation of China