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Bunse, T. ; Körber, N. ; Wintersteller, H.* ; Schneider, J.* ; Graf, A.* ; Radonić, A.* ; Thuermer, A.* ; von Kleist, M.* ; Blum, H.* ; Spinner, C.D.* ; Bauer, T. ; Knolle, P.A.* ; Protzer, U. ; Schulte, E.C.

T-cell-dominated immune response resolves protracted SARS-CoV-2 infection in the absence of neutralizing antibodies in an immunocompromised individual.

Microorganisms 11:1562 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual’s immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter B-and T-cell Immunity ; Immunocompromise ; Protracted Infection ; Sars-cov-2 ; Variants
ISSN (print) / ISBN 2076-2607
e-ISSN 2076-2607
Zeitschrift Microorganisms
Quellenangaben Band: 11, Heft: 6, Seiten: , Artikelnummer: 1562 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)