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Bramey, N. ; Schmeck, B.* ; Lehmann, M.

Aging and regeneration in the lung – Significance for COPD.

Atemwegs- Lungenkr. 49, 140-146 (2023)
DOI
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Lung transplantation remains the only curative option for patients with end-stage disease. A missing understanding of pathomechanisms and phenotypes of COPD hampers the development of novel therapeutic approaches. COPD is a disease of the aging population and is characterized by impaired regenerative capacity of the lung. Regenerative capacity is reduced in the aging lung which is caused by different cellular processes. Among those, cellular senescence is a main mechanism which is increased in COPD lungs. Cellular senescence impairs stem cell capacity and contributes to aging-associated chronic inflammation, so-called inflammaging. The therapeutic targeting of cellular senescence showed first promising results in preclinical experiments and suggests cellular senescence as a main target for personalized medicine approaches aiming at restoring the regenerative capacity of the COPD lung.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Aging ; Cellular Senescence ; Copd ; Regeneration ; Senolytics
ISSN (print) / ISBN 0341-3055
e-ISSN 0341-3055
Zeitschrift Atemwegs- und Lungenkrankheiten
Quellenangaben Band: 49, Heft: 4, Seiten: 140-146 Artikelnummer: , Supplement: ,
Verlag Dustri
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)