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Gado, M. ; Heinrich, A.* ; Wiedersich, D.* ; Sameith, K.* ; Dahl, A.* ; Alexaki, V.I.* ; Swarbrick, M.M.* ; Baschant, U.* ; Grafe, I.* ; Perakakis, N. ; Bornstein, S.R. ; Rauner, M.* ; Hofbauer, L.C.* ; Henneicke, H.*

Activation of β-adrenergic receptor signaling prevents glucocorticoid-induced obesity and adipose tissue dysfunction in male mice.

Am. J. Physiol. Endocrinol. Metab. 324, 514-530 (2023)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Elevated serum concentrations of glucocorticoids (GCs) result in excessive lipid accumulation in white adipose tissue (WAT) as well as dysfunction of thermogenic brown adipose tissue (BAT), ultimately leading to the development of obesity and metabolic disease. Here, we hypothesized that activation of the sympathetic nervous system either via cold exposure or the use of a selective b3-adrenergic receptor (b3-AR) agonist alleviates the adverse metabolic effects of chronic GC exposure in rodents. To this end, male 10-wk-old C57BL/6NRj mice were treated with corticosterone via drinking water or placebo for 4 wk while being maintained at 29°C (thermoneutrality), 22°C (room temperature), or 13°C (cold temperature); in a follow-up study mice received a selective b3-AR agonist or placebo with and without corticosterone while being maintained at room temperature. Body weight and food intake were monitored throughout the study. Histological and molecular analyses were performed on white and brown adipose depots. Cold exposure not only preserved the thermogenic function of brown adipose tissue but also reversed GC-induced lipid accumulation in white adipose tissue and corrected GC-driven obesity, hyperinsulinemia, and hyperglycemia. The metabolic benefits of cold exposure were associated with enhanced sympathetic activity in adipose tissue, thus potentially linking an increase in sympathetic signaling to the observed metabolic benefits. In line with this concept, chronic administration of a selective b3-AR agonist reproduced the beneficial metabolic effects of cold adaption during exposure to exogenous GCs. This preclinical study demonstrates the potential of b3-AR as a therapeutic target in the management and prevention of GC-induced metabolic disease. NEW & NOTEWORTHY This preclinical study in mice shows that the b3-adrenergic receptor can be a potential therapeutic approach to counteracting glucocorticoid (GC)-induced obesity and metabolic dysfunction. Both cold acclimation and b3-adrenergic receptor stimulation in a mouse model of excess glucocorticoids were adequate in not only preventing obesity, adiposity, and adipose tissue dysfunction but also correcting hyperinsulinemia, hyperleptinemia, and dyslipidemia.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adipose Tissue ; B 3-adrenergic Receptor Agonist ; Glucocorticoids ; Nonshivering Thermogenesis ; Obesity; Nonshivering Thermogenesis; Brown; Ucp1; Rna; Mechanisms; Mediate; Protein; Leptin
ISSN (print) / ISBN 0193-1849
e-ISSN 1522-1555
Zeitschrift American Journal of Physiology - Endocrinology and Metabolism
Quellenangaben Band: 324, Heft: 6, Seiten: 514-530 Artikelnummer: , Supplement: ,
Verlag American Physiological Society
Verlagsort 6120 Executive Blvd, Suite 600, Rockville, Md, United States
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)
Förderungen Elsbeth Bonhoff Stiftung
Deutsche Forschungsgemeinschaft (DFG)
Else Kroner Fresenius Foundation