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Chen, S.* ; Su, X.* ; Feng, Y.* ; Li, R.* ; Liao, M. ; Fan, L.* ; Liu, J.* ; Zhang, S.* ; Cai, J.* ; Zhu, S.* ; Niu, J.* ; Ye, Y.* ; Lo, K.* ; Zeng, F.*

Ketogenic diet and multiple health outcomes: An umbrella review of meta-analysis.

Nutrients 15:19 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Numerous studies have examined the effects of ketogenic diets (KD) on health-related outcomes through meta-analyses. However, the presence of biases may compromise the reliability of conclusions. Therefore, we conducted an umbrella review to collate and appraise the strength of evidence on the efficacy of KD interventions. We conducted a comprehensive search on PubMed, EMBASE, and the Cochrane Database until April 2023 to identify meta-analyses that investigated the treatment effects of KD for multiple health conditions, which yielded 23 meta-analyses for quantitative analyses. The evidence suggests that KD could increase the levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C), the respiratory exchange rate (RER), and could decrease total testosterone and testosterone levels (all p-random effects: <0.05). The combination of KD and physical activity can significantly reduce body weight and increase the levels of LDL-C and cortisol. In addition, KD was associated with seizure reduction in children, which can be explained by the ketosis state as induced by the diet. Furthermore, KD demonstrated a better alleviation effect in refractory childhood epilepsy, in terms of median effective rates for seizure reduction of ≥50%, ≥90%, and seizure freedom. However, the strength of evidence supporting the aforementioned associations was generally weak, thereby challenging their credibility. Consequently, future studies should prioritize stringent research protocols to ascertain whether KD interventions with longer intervention periods hold promise as a viable treatment option for various diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Cancer ; Ketogenic Diets ; Meta-analysis ; Obesity ; Overweight ; Seizure Reduction ; Umbrella Review; Environmental Risk-factors; Low-carbohydrate; Cardiovascular-disease; Diabetic-ketoacidosis; Efficacy; Management; Obesity; Lipoproteins; Restriction; Mechanisms
ISSN (print) / ISBN 2072-6643
e-ISSN 2072-6643
Zeitschrift Nutrients
Quellenangaben Band: 15, Heft: 19 Seiten: , Artikelnummer: 19 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Förderungen Natural Science Foundation of Guangdong Province - Youth Enhancement Project