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Starke, S.* ; Zwanenburg, A.* ; Leger, K.* ; Lohaus, F.* ; Linge, A.* ; Kalinauskaite, G.* ; Tinhofer, I.* ; Guberina, N.* ; Guberina, M.* ; Balermpas, P.* ; Grün, J.V.* ; Ganswindt, U. ; Belka, C. ; Peeken, J.C. ; Combs, S.E. ; Boeke, S.* ; Zips, D.* ; Richter, C.* ; Troost, E.G.C.* ; Krause, M.* ; Baumann, M.* ; Löck, S.*

Multitask learning with convolutional neural networks and vision transformers for outcome prediction of head and neck cancer patients

Cancers 15:21 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Neural-network-based outcome predictions may enable further treatment personalization of patients with head and neck cancer. The development of neural networks can prove challenging when a limited number of cases is available. Therefore, we investigated whether multitask learning strategies, implemented through the simultaneous optimization of two distinct outcome objectives (multi-outcome) and combined with a tumor segmentation task, can lead to improved performance of convolutional neural networks (CNNs) and vision transformers (ViTs). Model training was conducted on two distinct multicenter datasets for the endpoints loco-regional control (LRC) and progression-free survival (PFS), respectively. The first dataset consisted of pre-treatment computed tomography (CT) imaging for 290 patients and the second dataset contained combined positron emission tomography (PET)/CT data of 224 patients. Discriminative performance was assessed by the concordance index (C-index). Risk stratification was evaluated using log-rank tests. Across both datasets, CNN and ViT model ensembles achieved similar results. Multitask approaches showed favorable performance in most investigations. Multi-outcome CNN models trained with segmentation loss were identified as the optimal strategy across cohorts. On the PET/CT dataset, an ensemble of multi-outcome CNNs trained with segmentation loss achieved the best discrimination (C-index: 0.29, 95% confidence interval (CI): 0.22-0.36) and successfully stratified patients into groups with low and high risk of disease progression (p=0.003). On the CT dataset, ensembles of multi-outcome CNNs and of single-outcome ViTs trained with segmentation loss performed best (C-index: 0.26 and 0.26, CI: 0.18-0.34 and 0.18-0.35, respectively), both with significant risk stratification for LRC in independent validation (p=0.002 and p=0.011). Further validation of the developed multitask-learning models is planned based on a prospective validation study, which has recently completed recruitment.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cox Proportional Hazards ; Convolutional Neural Network ; Discrete-time Survival Models ; Head And Neck Cancer ; Loco-regional Control ; Multitask Learning ; Progression-free Survival ; Survival Analysis ; Tumor Segmentation ; Vision Transformer; Radiomics; Models
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2072-6694
Zeitschrift Cancers
Quellenangaben Band: 15, Heft: 19, Seiten: , Artikelnummer: 21 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Translational Metabolic Oncology (IDC-TMO)
Institute of Radiation Medicine (IRM)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-521800-001
G-501300-001
DOI 10.3390/cancers15194897
WOS ID 001095685500001
Scopus ID 85173848542
PubMed ID 37835591
Erfassungsdatum 2023-11-28
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