Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Stress-induced brain responses are associated with BMI in women.
Comm. Biol. 6:1031 (2023)
Overweight and obesity are associated with altered stress reactivity and increased inflammation. However, it is not known whether stress-induced changes in brain function scale with BMI and if such associations are driven by peripheral cytokines. Here, we investigate multimodal stress responses in a large transdiagnostic sample using predictive modeling based on spatio-temporal profiles of stress-induced changes in activation and functional connectivity. BMI is associated with increased brain responses as well as greater negative affect after stress and individual response profiles are associated with BMI in females (pperm < 0.001), but not males. Although stress-induced changes reflecting BMI are associated with baseline cortisol, there is no robust association with peripheral cytokines. To conclude, alterations in body weight and energy metabolism might scale acute brain responses to stress more strongly in females compared to males, echoing observational studies. Our findings highlight sex-dependent associations of stress with differences in endocrine markers, largely independent of peripheral inflammation.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Acute Psychosocial Stress; Body-mass Index; Sex-differences; Functional Connectivity; Gender-differences; Metabolic-syndrome; Limbic System; Hpa-axis; Obesity; Cortisol
ISSN (print) / ISBN
2399-3642
e-ISSN
2399-3642
Zeitschrift
Communications Biology
Quellenangaben
Band: 6,
Heft: 1,
Artikelnummer: 1031
Verlag
Springer
Verlagsort
London
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Computational Biology (ICB)
Förderungen
Brain Behaviour Research Foundation (NARSAD Young Investigator Grant)
Deutsche Forschungsgemeinschaft (DFG)
Deutsche Forschungsgemeinschaft (DFG)