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Ashe, S.* ; Hebrok, M.

Role of cell-based therapies in T2D.

Semin. Nephrol. 43:151432 (2023)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Type 2 diabetes mellitus (T2D) has become a global epidemic affecting the health of millions of people. T2D is a complex and multifactorial metabolic disease, largely characterized by a combination of impaired insulin secretion from β cells residing within the islets of the pancreas and peripheral insulin resistance. In this article, we discuss the current state and risk factors for T2D, conventional treatment options, and upcoming strategies, including progress in the areas of allogeneic and xenogeneic islet transplantation, with a major focus on stem cell-derived β cells and associated technologies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter T(reg) Therapy ; Type 2 Diabetes Mellitus ; Clinical Trials ; Immune Modulation ; Stem Cell Therapy ; β Cells; Beta-cells; Pancreatic Progenitors; Maturation; Challenges; Generation; Reversal
ISSN (print) / ISBN 0270-9295
Zeitschrift Seminars in Nephrology
Quellenangaben Band: 43, Heft: 3, Seiten: , Artikelnummer: 151432 Supplement: ,
Verlag Elsevier
Verlagsort Philadelphia
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Diabetes und Organoid Technology (IDOT)
Förderungen Juvenile Diabetes Research Foundation-JDRF
National Institutes of Health
Bayer Corporation