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Kreitmaier, P. ; Park, Y.-C. ; Swift, D.* ; Gilly, A. ; Wilkinson, J.M.* ; Zeggini, E.

Epigenomic profiling of the infrapatellar fat pad in osteoarthritis.

Hum. Mol. Genet. 33:ddad198 (2023)
Postprint DOI PMC
Open Access Gold (Paid Option)
Osteoarthritis is a prevalent, complex disease of the joints, and affects multiple intra-articular tissues. Here, we have examined genome-wide DNA methylation profiles of primary infrapatellar fat pad and matched blood samples from 70 osteoarthritis patients undergoing total knee replacement surgery. Comparing the DNA methylation profiles between these tissues reveal widespread epigenetic differences. We produce the first genome-wide methylation quantitative trait locus (mQTL) map of fat pad, and make the resource available to the wider community. Using two-sample Mendelian randomization and colocalization analyses, we resolve osteoarthritis GWAS signals and provide insights into the molecular mechanisms underpinning disease aetiopathology. Our findings provide the first view of the epigenetic landscape of infrapatellar fat pad primary tissue in osteoarthritis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Dna Methylation ; Ewas ; Infrapatellar Fat Pad ; Methylation Qtl ; Osteoarthritis; Knee Osteoarthritis; Synoviocytes; Expression; Package; Disease; Tissue; Power
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Zeitschrift Human Molecular Genetics
Quellenangaben Band: 33, Heft: 6, Seiten: , Artikelnummer: ddad198 Supplement: ,
Verlag Oxford University Press
Verlagsort Great Clarendon St, Oxford Ox2 6dp, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Translational Genomics (ITG)
Förderungen Wellcome Trust