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Correa-Gallegos, D. ; Ye, H. ; Dasgupta, B. ; Sardogan, A. ; Kadri, S. ; Kandi, R. ; Dai, R. ; Lin, Y. ; Kopplin, R. ; Shantaram Shenai, D. ; Wannemacher, J. ; Ichijo, R. ; Jiang, D. ; Strunz, M. ; Ansari, M. ; Angelidis, I. ; Schiller, H. ; Voltz, T.* ; Machens, H.G.* ; Rinkevich, Y.

CD201+ fascia progenitors choreograph injury repair.

Nature 623, 792-802 (2023)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of tissue inflammation, contraction and scar formation1. Here we identify a multipotent fibroblast progenitor marked by CD201 expression in the fascia, the deepest connective tissue layer of the skin. Using skin injury models in mice, single-cell transcriptomics and genetic lineage tracing, ablation and gene deletion models, we demonstrate that CD201+ progenitors control the pace of wound healing by generating multiple specialized cell types, from proinflammatory fibroblasts to myofibroblasts, in a spatiotemporally tuned sequence. We identified retinoic acid and hypoxia signalling as the entry checkpoints into proinflammatory and myofibroblast states. Modulating CD201+ progenitor differentiation impaired the spatiotemporal appearances of fibroblasts and chronically delayed wound healing. The discovery of proinflammatory and myofibroblast progenitors and their differentiation pathways provide a new roadmap to understand and clinically treat impaired wound healing.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dermal Fibroblasts; Hypoxia; Skin; Transition; Cells; Differentiation; Fibrosis
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Zeitschrift Nature
Quellenangaben Band: 623, Heft: 7988, Seiten: 792-802 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology and Medicine (IRBM)
German Center for Lung Research (DZL)
Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
Forschungsfeld(er) Lung Research
PSP-Element(e) G-509400-001
G-501800-810
G-501693-001
Förderungen European Foundation for the Study of Diabetes (EFSD) Anniversary Fund Program
LEO Foundation
European Research Council
DOI 10.1038/s41586-023-06725-x
WOS ID 001113654700001
WOS ID 001105882300015
Scopus ID 85176382144
PubMed ID 37968392
Erfassungsdatum 2023-11-28
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