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Structural changes of CA1 pyramidal neurons after stroke in the contralesional hippocampus.
Brain Pathol.:e13222 (2023)
Significant progress has been made with regard to understanding how the adult brain responds after a stroke. However, a large number of patients continue to suffer lifelong disabilities without adequate treatment. In the present study, we have analyzed possible microanatomical alterations in the contralesional hippocampus from the ischemic stroke mouse model tMCAo 12-14 weeks after transient middle cerebral artery occlusion. After individually injecting Lucifer yellow into pyramidal neurons from the CA1 field of the hippocampus, we performed a detailed three-dimensional analysis of the neuronal complexity, dendritic spine density, and morphology. We found that, in both apical (stratum radiatum) and basal (stratum oriens) arbors, CA1 pyramidal neurons in the contralesional hippocampus of tMCAo mice have a significantly higher neuronal complexity, as well as reduced spine density and alterations in spine volume and spine length. Our results show that when the ipsilateral hippocampus is dramatically damaged, the contralesional hippocampus exhibits several statistically significant selective alterations. However, these alterations are not as significant as expected, which may help to explain the recovery of hippocampal function after stroke. Further anatomical and physiological studies are necessary to better understand the modifications in the "intact" contralesional lesioned brain regions, which are probably fundamental to recover functions after stroke.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Contralesonal Hemisphere ; Dendritic Spines ; Intracellular Injections ; Neuronal Complexity ; Tmcao; Growth-associated Gene; Dendritic Spines; Functional Recovery; Cerebral-ischemia; Region; Brain; Reorganization; Integration; Impairment; Mechanisms
ISSN (print) / ISBN
1015-6305
e-ISSN
1750-3639
Zeitschrift
Brain Pathology
Quellenangaben
Artikelnummer: e13222
Verlag
Wiley
Verlagsort
111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Tissue Engineering and Regenerative Medicine (ITERM)
Förderungen
Spanish Ministry of Universities
MCIN/AEI
ERA-NETNEURON
Deutsche Forschungsgemeinschaft
Centro de Investigacion Biomedica en Redsobre Enfermedades Neurodegenerativas
MCIN/AEI
ERA-NETNEURON
Deutsche Forschungsgemeinschaft
Centro de Investigacion Biomedica en Redsobre Enfermedades Neurodegenerativas