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Copper incorporated biomaterial-based technologies for multifunctional wound repair.
Theranostics 14, 547-570 (2024)
The treatment of wounds is a worldwide challenge, and wound infection can affect the effectiveness of wound treatment and further increase the disease burden. Copper is an essential trace element that has been shown to have broad-spectrum antibacterial effects and to be involved in the inflammation, proliferation, and remodeling stages of wound healing. Compared to treatments such as bioactive factors and skin grafts, copper has the advantage of being low-cost and easily available, and has received a lot of attention in wound healing. Recently, biomaterials made by incorporating copper into bioactive glasses, polymeric scaffolds and hydrogels have been used to promote wound healing by the release of copper ions. In addition, copper-incorporated biomaterials with catalytic, photothermal, and photosensitive properties can also accelerate wound healing through antibacterial and wound microenvironment regulation. This review summarizes the antibacterial mechanisms of copper- incorporated biomaterials and their roles in wound healing, and discusses the current challenges. A comprehensive understanding of the role of copper in wounds will help to facilitate new preclinical and clinical studies, thus leading to the development of novel therapeutic tools.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Antibacterial ; Copper ; Nanozyme ; Photodynamic Therapy ; Photothermal Therapy; Endothelial Growth-factor; Nf-kappa-b; Bioactive Glass; In-vitro; Matrix Metalloproteinases; Antibacterial Activity; Nanoparticles; Therapy; Expression; Skin
e-ISSN
1838-7640
Zeitschrift
Theranostics
Quellenangaben
Band: 14,
Heft: 2,
Seiten: 547-570
Verlag
Ivyspring
Verlagsort
Po Box 4546, Lake Haven, Nsw 2263, Australia
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Regenerative Biology (IRBM)
Förderungen
Incentive Fund from the University of Groningen
People's Republic of China Ministry of Education, Science, and Technology Development Center
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Department of Science and Technology of Hubei Province
People's Republic of China Ministry of Education, Science, and Technology Development Center
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Department of Science and Technology of Hubei Province