PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Zeng, R.* ; Lv, B.* ; Lin, Z.* ; Chu, X.* ; Xiong, Y.* ; Knoedler, S. ; Cao, F.* ; Lin, C.* ; Chen, L.* ; Yu, C.* ; Liao, J.M.* ; Zhou, W.* ; Dai, G.* ; Shahbazi, M.A.* ; Mi, B.* ; Liu, G.*

Neddylation suppression by a macrophage membrane-coated nanoparticle promotes dual immunomodulatory repair of diabetic wounds.

Bioact. Mater. 34, 366-380 (2024)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Oxidative stress, infection, and vasculopathy caused by hyperglycemia are the main barriers for the rapid repair of foot ulcers in patients with diabetes mellitus (DM). In recent times, the discovery of neddylation, a new type of post-translational modification, has been found to regulate various crucial biological processes including cell metabolism and the cell cycle. Nevertheless, its capacity to control the healing of wounds in diabetic patients remains unknown. This study shows that MLN49224, a compound that inhibits neddylation at low concentrations, enhances the healing of diabetic wounds by inhibiting the polarization of M1 macrophages and reducing the secretion of inflammatory factors. Moreover, it concurrently stimulates the growth, movement, and formation of blood vessel endothelial cells, leading to expedited healing of wounds in individuals with diabetes. The drug is loaded into biomimetic macrophage-membrane-coated PLGA nanoparticles (M-NPs/MLN4924). The membrane of macrophages shields nanoparticles from being eliminated in the reticuloendothelial system and counteracts the proinflammatory cytokines to alleviate inflammation in the surrounding area. The extended discharge of MLN4924 from M-NPs/MLN4924 stimulates the growth of endothelial cells and the formation of tubes, along with the polarization of macrophages towards the anti-inflammatory M2 phenotype. By loading M-NPs/MLN4924 into a hydrogel, the final formulation is able to meaningfully repair a diabetic wound, suggesting that M-NPs/MLN4924 is a promising engineered nanoplatform for tissue engineering.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Altmetric
18.000
2.702
2
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Biomimetic Nanoparticle ; Diabetes ; Macrophage Polarization ; Macrophages Cell Membranes ; Wound Healing; Nedd8-activating Enzyme; Inhibitor
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 2452-199X
e-ISSN 2452-199X
Zeitschrift Bioactive Materials
Quellenangaben Band: 34, Heft: , Seiten: 366-380 Artikelnummer: , Supplement: ,
Verlag KeAi Communications Co.
Verlagsort 16 Donghuangchenggen North St, Building 5, Room 411, Beijing, Dongcheng District 100009, Peoples R China
Institut(e) Institute of Regenerative Biology and Medicine (IRBM)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-509400-001
Förderungen Scientific Research Project in Health System of Pingshan District
Medical Research Foundation of Guangdong Province
Natural Science Foundation of Shenzhen Municipality
Hubei Province Unveiling Science and Technology Projects
Chinese Pharmaceutical Association Hospital Pharmacy department
Department of Science and Technology of Hubei Province
Wuhan Science and Tech-nology Bureau
National Science Foundation of China
DOI 10.1016/j.bioactmat.2023.12.025
WOS ID 001214150200001
Scopus ID 85181812436
PubMed ID 38269308
Erfassungsdatum 2024-01-16
[➜Korrektur melden]