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Choudhary, P.* ; Monasso, G.S.* ; Karhunen, V.* ; Ronkainen, J.* ; Mancano, G.* ; Howe, C.G.* ; Niu, Z.* ; Zeng, X.* ; Guan, W.* ; Dou, J.* ; Feinberg, J.I.* ; Mordaunt, C.* ; Pesce, G.* ; Baïz, N.* ; Alfano, R.* ; Martens, D.S.* ; Wang, C.* ; Isaevska, E.* ; Keikkala, E.* ; Mustaniemi, S.* ; Thio, C.H.L.* ; Fraszczyk, E.* ; Tobi, E.W.* ; Starling, A.P.* ; Cosin-Tomas, M.* ; Urquiza, J.* ; Roeder, S.* ; Hoang, T.T.* ; Page, C.M.* ; Jima, D.D.* ; House, J.S.* ; Maguire, R.L.* ; Ott, R. ; Pawlow, X. ; Sirignano, L.* ; Zillich, L.* ; Malmberg, A.* ; Rauschert, S.* ; Melton, P.* ; Gong, T.* ; Karlsson, R.* ; Fore, R.* ; Perng, W.* ; Laubach, Z.M.* ; Czamara, D.* ; Sharp, G.C.* ; Breton, C.V.* ; Schisterman, E.* ; Yeung, E.* ; Mumford, S.L.* ; Fallin, M.D.* ; LaSalle, J.M.* ; Schmidt, R.J.* ; Bakulski, K.M.* ; Annesi-Maesano, I.* ; Heude, B.* ; Nawrot, T.S.* ; Plusquin, M.* ; Ghantous, A.* ; Herceg, Z.* ; Nisticò, L.* ; Vafeiadi, M.* ; Kogevinas, M.* ; Vaeaeraesmaeki, M.* ; Kajantie, E.* ; Snieder, H.* ; Corpeleijn, E.* ; Steegers-Theunissen, R.P.M.* ; Yang, I.V.* ; Dabelea, D.* ; Fossati, S.* ; Zenclussen, A.C.* ; Herberth, G.* ; Magnus, M.C.* ; Haberg, S.E.* ; London, S.J.* ; Munthe-Kaas, M.C.* ; Murphy, S.K.* ; Hoyo, C.* ; Ziegler, A.-G. ; Hummel, S. ; Witt, S.H.* ; Streit, F.* ; Frank, J.* ; Raeikkoenen, K.* ; Lahti, J.* ; Huang, R.* ; Almqvist, C.* ; Hivert, M.-F.* ; Jaddoe, V.W.V.* ; Jaervelin, M.* ; Kantomaa, M.* ; Felix, J.F.* ; Sebert, S.*

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence.

Mol. Psychiatry, DOI: 10.1038/s41380-023-02331-5 (2023)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Smoking; Discovery; Newborns; Health
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 1359-4184
e-ISSN 1476-5578
Zeitschrift Molecular Psychiatry
Verlag Nature Publishing Group
Verlagsort Campus, 4 Crinan St, London, N1 9xw, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502100-001
Förderungen European Union
DOI 10.1038/s41380-023-02331-5
WOS ID 001118888000002
PubMed ID 38052982
Erfassungsdatum 2024-01-16
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