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Hellbach, F.* ; Freuer, D.* ; Meisinger, C.* ; Peters, A. ; Winkelmann, J. ; Costeira, R.* ; Hauner, H.* ; Baumeister, S.E.* ; Bell, J.T.* ; Waldenberger, M. ; Linseisen, J.*

Usual dietary intake and change in DNA methylation over years: EWAS in KORA FF4 and KORA fit.

Front. Nutr. 10:1295078 (2024)
DOI PMC
Creative Commons Lizenzvertrag
Introduction: Changes in DNA methylation can increase or suppress the expression of health-relevant genes. We investigated for the first time the relationship between habitual food consumption and changes in DNA methylation. Methods: The German KORA FF4 and KORA Fit studies were used to study the change in methylation over a median follow-up of 4 years. Only subjects participating in both surveys and with available dietary and methylation data were included in the analysis (n = 465). DNA methylation was measured using the Infinium MethylationEPIC BeadChip (Illumina), resulting in 735,527 shared CpGs across both studies. Generalized estimating equation models with an interaction term of exposure and time point were used to analyze the association of 34 food groups, folic acid, and two dietary patterns with changes in DNA methylation over time. Results: The results were corrected for genomic inflation. Significant interaction terms indicate different effects between both time points. We observed only a few significant associations between food intake and change in DNA methylation, except for cream and spirit consumption. The annotated genes include CLN3, PROM1, DLEU7, TLL2, and UGT1A10. Discussion: We identified weak associations between food consumption and DNA methylation change. The differential results for cream and spirits, both consumed in low quantities, require replication in independent studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Diet ; Dna Methylation ; Epidemiology ; Food Group ; Usual Dietary Intake; Vitamin-b-12; Association; Folate; Risk
ISSN (print) / ISBN 2296-861X
e-ISSN 2296-861X
Zeitschrift Frontiers in Nutrition
Quellenangaben Band: 10, Heft: , Seiten: , Artikelnummer: 1295078 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Institute of Neurogenomics (ING)
Förderungen European HDHL JPI funding scheme