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Nagel, G.* ; Chen, J.* ; Jaensch, A.* ; Skodda, L.* ; Rodopoulou, S.* ; Strak, M.* ; de Hoogh, K.* ; Andersen, Z.J.* ; Bellander, T.* ; Brandt, J.* ; Fecht, D.* ; Forastiere, F.* ; Gulliver, J.* ; Hertel, O.* ; Hoffmann, B.* ; Hvidtfeldt, U.A.* ; Katsouyanni, K.* ; Ketzel, M.* ; Leander, K.* ; Magnusson, P.K.E.* ; Pershagen, G.* ; Rizzuto, D.* ; Samoli, E.* ; Severi, G.* ; Stafoggia, M.* ; Tjønneland, A.* ; Vermeulen, R.C.H.* ; Wolf, K. ; Zitt, E.* ; Brunekreef, B.* ; Hoek, G.* ; Raaschou-Nielsen, O.* ; Weinmayr, G.*

Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project.

Int. J. Cancer 154, 1900-1910 (2024)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N = 287,576 participants for gastric and N = 297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM2.5 ), nitrogen dioxide (NO2 ), black carbon (BC) and ozone in the warm season (O3w ) with gastric and UADT cancer. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. During 5,305,133 and 5,434,843 person-years, 872 gastric and 1139 UADT incident cancer cases were observed, respectively. For gastric cancer, we found no association with PM2.5 , NO2 and BC while for UADT the hazard ratios (95% confidence interval) were 1.15 (95% CI: 1.00-1.33) per 5 μg/m3 increase in PM2.5 , 1.19 (1.08-1.30) per 10 μg/m3 increase in NO2 , 1.14 (1.04-1.26) per 0.5 × 10-5  m-1 increase in BC and 0.81 (0.72-0.92) per 10 μg/m3 increase in O3w . We found no association between long-term ambient air pollution exposure and incidence of gastric cancer, while for long-term exposure to PM2.5 , NO2 and BC increased incidence of UADT cancer was observed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Uadt ; Air Pollution ; Gastric Cancer ; Nitrogen Dioxide ; Ozone ; Particular Matter; Use Regression-models; Men; Population; Profile; Risk; No2; Mortality; Health; Women; Pm2.5
ISSN (print) / ISBN 0020-7136
e-ISSN 1097-0215
Zeitschrift International Journal of Cancer
Quellenangaben Band: 154, Heft: 11, Seiten: 1900-1910 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Förderungen Deutsche Krebshilfe