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Schweiger, M. ; Arredondo-Lasso, M.N. ; Friano, M.E. ; Gil Lozano, M. ; Herzig, S. ; Uhlenhaut, N.H.

Lipid sensing nuclear receptors involved in the pathogenesis of fatty liver disease.

FEBS Lett., DOI: 10.1002/1873-3468.14818 (2024)
DOI PMC
Creative Commons Lizenzvertrag
Non-alcoholic fatty liver disease (NAFLD) begins with lipid accumulation and progresses toward inflammation and fibrosis. Nuclear receptors (NRs), like the Peroxisome Proliferator-Activated Receptors alpha and gamma (PPARα and PPARy), the Farnesoid X Receptor (FXR), and the Liver X receptor (LXR), regulate genes by heterodimerizing with Retinoid X receptor (RXR). These receptors are emerging targets for pharmaceutical intervention for metabolic diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Letter to the Editor
Korrespondenzautor
Schlagwörter Fxr ; Lxr ; Nafld ; Nash ; Pparalpha ; Ppargamma ; Fibrosis ; Nuclear Receptors; Farnesoid X Receptor; Nonalcoholic Steatohepatitis; Ppar-alpha; Bile-acid; Cholesterol; Metabolism; Fibrosis; Agonist
ISSN (print) / ISBN 0014-5793
e-ISSN 1873-3468
Zeitschrift FEBS Letters
Verlag Elsevier
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Endocrinology (IDE)
Institute of Diabetes and Cancer (IDC)
Förderungen German Research Foundation DFG