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Fechner, J.* ; Contreras, M.P.* ; Zorzo, C.* ; Shan, X.* ; Born, J. ; Inostroza, M.*

Sleep slow oscillation-spindle coupling precedes spindle-ripple coupling during development.

Sleep 47:zsae061 (2024)
DOI PMC
Open Access Green: Postprint online verfügbar 05/2025
STUDY OBJECTIVES: Sleep supports systems memory consolidation through the precise temporal coordination of specific oscillatory events during slow-wave sleep (SWS), i.e., the neocortical slow oscillations (SOs), thalamic spindles, and hippocampal ripples. Beneficial effects of sleep on memory are also observed in infants, although the contributing regions, especially hippocampus and frontal cortex, are immature. Here, we examined in rats the development of these oscillatory events and their coupling during early life. METHODS: EEG and hippocampal local field potentials (LFPs) were recorded during sleep in male rats at postnatal days (PD)26 and 32, roughly corresponding to early (1-2 years) and late (9-10 years) human childhood, and in a group of adult rats (14-18 weeks, corresponding to ~22-29 years in humans). RESULTS: SO and spindle amplitudes generally increased from PD26 to PD32. In parallel, frontocortical EEG spindles increased in density and frequency, while changes in hippocampal ripples remained non-significant. The proportion of SOs co-occurring with spindles also increased from PD26 to PD32. Whereas parietal cortical spindles were phase-locked to the depolarizing SO-upstate already at PD26, over frontal cortex SO-spindle phase-locking emerged not until PD32. Co-occurrence of hippocampal ripples with spindles was higher during childhood than in adult rats, but significant phase-locking of ripples to the excitable spindle troughs was observed only in adult rats. CONCLUSIONS: Results indicate a protracted development of synchronized thalamocortical processing specifically in frontocortical networks (i.e., frontal SO-spindle coupling). However, synchronization within thalamocortical networks generally precedes synchronization of thalamocortical with hippocampal processing as reflected by the delayed occurrence of spindle-ripple phase-coupling.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Development ; Cortex ; Hippocampus ; Ripple ; Slow Oscillation ; Spindles; Brain Maturation; Gray-matter; Rat; Humans; Age; Homeostasis; Plasticity; Childhood; Emergence; Density
ISSN (print) / ISBN 0161-8105
e-ISSN 1550-9109
Zeitschrift Sleep
Quellenangaben Band: 47, Heft: 5, Seiten: , Artikelnummer: zsae061 Supplement: ,
Verlag American Academy of Sleep Medicine and the Sleep Research Society
Verlagsort Journals Dept, 2001 Evans Rd, Cary, Nc 27513 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)