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Urbano, T.* ; Filippini, T.* ; Malavolti, M.* ; Michalke, B. ; Fustinoni, S.* ; Vinceti, M.*

Selenium exposure and oxidative stress and genotoxicity risk in a healthy Italian population: a cross sectional study.

In:. European Publishing, 2023. DOI: 10.18332/popmed/165301 (Popul. Med. ; 5)

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Background and Objective: The relation between selenium and cellular redox status is a greatly debated topic in human health. 8-oxo-7, 8-dihydro-2’deoxyguanosine (8-oxodG) is an oxidized derivative of deoxyguanosine and a sensitive biomarker of oxidative stress and genotoxicity. The present study assessed the extent to which selenium status was associated with urinary 8-oxodG concentrations in a Northern Italian population. Methods: Of 148 eligible subjects, 137 healthy and non-smoking blood donors living in the Reggio Emilia province during 2017–2019 were enrolled. We measured urinary 8-oxodG concentrations and used restricted cubic spline regression analyses to investigate the association between selenium status (estimated using food frequency questionnaires, urinary concentrations, and serum concentrations of selenium and selenium species) and 8-oxodG/g creatinine. Results:Median age of our population was 48.2 years. Median urinary selenium and 8-oxodG levels (n=137) were 22.02 µg/L and 3.21 µg/g creatinine, respectively. Median total serum (n=104) concentrations were 116.50 µg/L, while median dietary intake (n=137) was 78.7 µg/day. Little association between dietary, serum, or urinary selenium with 8-oxodG concentrations emerged in the overall population. Urinary selenium positively correlated with 8-oxodG levels in men, while in women an inverted U-shaped association emerged. Total organic selenium and selenoprotein P levels were positively associated with 8-oxodG until 100 µg/L and then the association became slightly inverse in both sexes. In males, glutathione peroxidase-bound selenium and selenomethionine were positively correlated with 8-oxodG, while negative associations emerged for inorganic species. In females, positive but weak associations emerged for organic selenium species. Conclusions: Results of our study suggest that even though total selenium exposure seems not associated with 8-oxodG, selected selenium species may largely differ in their association with this oxidative stress biomarker, and that effects modification by sex was encountered. Selenomethionine-bound selenium was the organic compound most strongly associated with 8-oxodG.

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