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Guan, C.* ; Li, C.* ; Yang, C.* ; Yang, D.* ; Zhang, L.* ; Xu, L.* ; Liu, K.* ; Zhang, N.* ; Li, T.* ; Song, Z.* ; Che, L.* ; Wang, Y.* ; Zhang, L. ; Li, D.* ; Zhu, Y.* ; Xu, Y.*

Enhanced renal carcinomat treatment via synergistic photothermal/photodynamic therapy using hittorf's phosphorus-decorated polymeric carbon nitride heterostructure.

Adv. Opt. Mater. 2024:2303318 (2024)
Verlagsversion DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Nanostructured heterojunctions offer a promising solution to overcome the limitations of narrow absorption spectra, limited penetration depths, and potential harm to healthy cells in phototherapy for clear cell renal cell carcinoma (ccRCC) treatment with nanomaterials. In this study, a heterostructure (PCN@HP) by decorating Hittorf's phosphorus nanorods onto biocompatible polymeric carbon nitride (PCN), enabling excitation by NIR light is designed. Compared with PCN and HP alone, the synthesized heterostructure generated localized heat upon broad absorption spectra of irradiation, boosting charge migration and separation, generating cytotoxic reactive oxygen species (ROS). Then, via in vitro and in vivo experiments, it is confirmed that the NIR-mediated PCN@HP heterojunction is a safe and effective approach for synchronous photothermal and photodynamic therapy treatment of ccRCC. Collectively, the PCN@HP heterojunction holds great potential as a non-invasive synergistic, dual-mode therapeutic nanomedicine for efficient tumor nano-therapy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Clear Cell Renal Cell Carcinoma ; Hittorf's Phosphorus ; Mild Photothermal Therapy ; Photodynamic Therapy; Photothermal Therapy; Cell Carcinoma; Photodynamic Therapy; Tumor; Nanoparticles; Nanomaterials; Resistance
ISSN (print) / ISBN 2195-1071
e-ISSN 2195-1071
Zeitschrift Advanced Optical Materials
Quellenangaben Band: 2024, Heft: , Seiten: , Artikelnummer: 2303318 Supplement: ,
Verlag Wiley
Verlagsort Postfach 101161, 69451 Weinheim, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)