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Wang, F.* ; Zhong, Y.* ; Bruns, O.T. ; Liang, Y.* ; Dai, H.*

In vivo NIR-II fluorescence imaging for biology and medicine.

Nat. Photonics, DOI: 10.1038/s41566-024-01391-5 (2024)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Owing to reduced light scattering and tissue autofluorescence, in vivo fluorescence imaging in the 1,000–3,000-nm near-infrared II (NIR-II) spectral range can afford non-invasive imaging at depths of millimetres within biological tissue. Infrared fluorescent probes labelled with antibodies or other targeting ligands also enable NIR-II molecular imaging at the single-cell level. Here we present recent developments in the design of fluorophores and probes emitting in the NIR-II window based on organic synthesis and nanoscience approaches. We also review advances in NIR-II wide-field and microscopy imaging modalities, with a focus on preclinical imaging and promising clinical translation case studies. Finally, we outline current issues and challenges for the wider adoption of NIR-II imaging in biomedical research and clinical imaging.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Carbon Nanotubes; Molecular Fluorophores; Microscopy; Deep; Systems; Window; Donor; Brain; Dye
ISSN (print) / ISBN 1749-4885
e-ISSN 1749-4893
Zeitschrift Nature Photonics
Verlag Nature Publishing Group
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)
Förderungen National Institutes of Health
U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review)