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Del-Valle-Anton, L.* ; Amin, S.A.* ; Cimino, D. ; Neuhaus, F.* ; Dvoretskova, E.* ; Fernandez, V.* ; Babal, Y.K.* ; Garcia-Frigola, C.* ; Prieto-Colomina, A.* ; Murcia-Ramón, R.* ; Nomura, Y.* ; Cárdenas, A.* ; Feng, C.* ; Moreno-Bravo, J.A.* ; Götz, M. ; Mayer, C.* ; Borrell, V.*

Multiple parallel cell lineages in the developing mammalian cerebral cortex.

Sci. Adv. 10:eadn9998 (2024)
Verlagsversion DOI PMC
Creative Commons Lizenzvertrag
Cortical neurogenesis follows a simple lineage: apical radial glia cells (RGCs) generate basal progenitors, and these produce neurons. How this occurs in species with expanded germinal zones and a folded cortex, such as human, remains unclear. We used single-cell RNA sequencing from individual cortical germinal zones in ferret and barcoded lineage tracking to determine the molecular diversity of progenitor cells and their lineages. We identified multiple RGC classes that initiate parallel lineages, converging onto a common class of newborn neuron. Parallel RGC classes and transcriptomic trajectories were repeated across germinal zones and conserved in ferret and human, but not in mouse. Neurons followed parallel differentiation trajectories in the gyrus and sulcus, with different expressions of human cortical malformation genes. Progenitor cell lineage multiplicity is conserved in the folded mammalian cerebral cortex.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Zeitschrift Science Advances
Quellenangaben Band: 10, Heft: 13, Seiten: , Artikelnummer: eadn9998 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington, DC [u.a.]
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)