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Shmal, D.* ; Mantero, G.* ; Floss, T. ; Benfenati, F.* ; Maya-Vetencourt, J.F.*

Restoring vision in adult amblyopia by enhancing plasticity through deletion of the transcriptional repressor REST.

iScience 27:109507 (2024)
Verlagsversion DOI PMC
Creative Commons Lizenzvertrag
Visual cortical plasticity is high during early life, but gradually decreases with development. This is due to the Otx2-driven maturation of intracortical inhibition that parallels the condensation of extracellular matrix components into perineuronal nets mainly around parvalbumin-positive GABAergic neurons. Repressor Element 1 Silencing Transcription (REST) epigenetically controls the expression of a plethora of neuron-specific genes. We demonstrate that the conditional knockout of REST in the primary visual cortex of adult mice induces a shift of ocular dominance after short-term monocular deprivation and promotes the recovery of vision in long-term deprived animals after reverse suture. These phenomena paralleled a reduction of perineuronal net density and increased expression of REST target genes, but not of the homeoprotein Otx2 in the visual cortex contralateral to the deprived eye. This shows that REST regulates adult visual cortical plasticity and is a potential therapeutic target to restore vision in adult amblyopia by enhancing V1 plasticity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Biological Sciences ; Natural Sciences ; Neuroscience ; Sensory Neuroscience ; Systems Neuroscience; Ocular Dominance Plasticity; Visual-cortex; Critical-period; Monocular Deprivation; Regulates Plasticity; In-vivo; Expression; Recovery; Reactivation; Activation
ISSN (print) / ISBN 2589-0042
e-ISSN 2589-0042
Zeitschrift iScience
Quellenangaben Band: 27, Heft: 4, Seiten: , Artikelnummer: 109507 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam ; Bosten ; London ; New York ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
Förderungen IRCCS Ospedale Policlinico San Martino
Compagnia di San Paolo Torino
Italian Ministry of University and Research