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Zocher, S.* ; McCloskey, A.* ; Karasinsky, A.* ; Schulte, R.* ; Friedrich, U.A. ; Lesche, M.* ; Rund, N.* ; Gage, F.H.* ; Hetzer, M.W.* ; Toda, T.*

Lifelong persistence of nuclear RNAs in the mouse brain.

Science 384, 53-59 (2024)
Postprint DOI PMC
Open Access Green
Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. In this work, we identified and characterized nuclear RNAs that do not turn over for at least 2 years in a subset of postnatally born cells in the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural cell type-specific manner and were required for the maintenance of heterochromatin. Thus, the life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information and also the extreme stability of RNA for the functional organization of chromatin.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Messenger-rna; Neurogenesis; Transcription; Proteins; Reveals; Package
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 384, Heft: 6691, Seiten: 53-59 Artikelnummer: , Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
PSP-Element(e) A-502600-001
Förderungen Deutsche Forschungsgemeinschaft
Nomis Foundation
DZNE
European Research Council
Boehringer Ingelheim Foundation
DOI 10.1126/science.adf3481
WOS ID 001253335100031
Scopus ID 85189676739
PubMed ID 38574132
Erfassungsdatum 2024-05-24
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