PuSH - Publikationsserver des Helmholtz Zentrums München

Holz, A.* ; Obi, N.* ; Ahrens, W.* ; Berger, K.* ; Bohn, B.* ; Brenner, H.* ; Fischer, B.* ; Fricke, J.* ; Führer, A.* ; Gastell, S.* ; Greiser, K.H.* ; Harth, V.* ; Heise, J.K.* ; Holleczek, B.* ; Keil, T.* ; Klett-Tammen, C.J.* ; Leitzmann, M.* ; Lieb, W.* ; Meinke-Franze, C.* ; Michels, K.B.* ; Mikolajczyk, R.* ; Nimptsch, K.* ; Peters, A. ; Pischon, T.* ; Riedel, O.* ; Schikowski, T.* ; Schipf, S.* ; Schmidt, B.* ; Schulze, M.B.* ; Stang, A.* ; Hellwig, K.* ; Riemann-Lorenz, K.* ; Heesen, C.* ; Becher, H.*

Childhood and adolescence factors and multiple sclerosis: Results from the German National Cohort (NAKO).

BMC Neurology 24:123 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Multiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We aimed to investigate the association between various factors (e.g., prematurity, breastfeeding, daycare attendance, weight history) and MS risk. METHODS: Data from the baseline assessment of the German National Cohort (NAKO) were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between childhood and adolescence factors and risk of MS. Analyses stratified by sex were conducted. RESULTS: Among a total of 204,273 participants, 858 reported an MS diagnosis. Male sex was associated with a decreased MS risk (HR 0.48; 95% CI 0.41-0.56), while overweight (HR 2.03; 95% CI 1.41-2.94) and obesity (HR 1.89; 95% CI 1.02-3.48) at 18 years of age compared to normal weight were associated with increased MS risk. Having been breastfed for ≤ 4 months was associated with a decreased MS risk in men (HR 0.59; 95% CI 0.40-0.86) compared to no breastfeeding. No association with MS risk was observed for the remaining factors. CONCLUSIONS: Apart from overweight and obesity at the age of 18 years, we did not observe considerable associations with MS risk. The proportion of cases that can be explained by childhood and adolescence factors examined in this study was low. Further investigations of the association between the onset of overweight and obesity in childhood and adolescence and its interaction with physical activity and MS risk seem worthwhile.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adolescence ; Childhood ; Epidemiology ; Multiple Sclerosis; Early-life; Age 20; Risk; Exposure; Birth; Prevention; Weight; Burden
e-ISSN 1471-2377
Zeitschrift BMC Neurology
Quellenangaben Band: 24, Heft: 1, Seiten: , Artikelnummer: 123 Supplement: ,
Verlag BioMed Central
Verlagsort Campus, 4 Crinan St, London N1 9xw, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Förderungen Universittsklinikum Hamburg-Eppendorf (UKE) (5411)