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Hepatitis B virus neutralization with DNA origami nanoshells.
ACS Appl. Mater. Interfaces 16, 25836-25842 (2024)
We demonstrate the use of DNA origami to create virus-trapping nanoshells that efficiently neutralize hepatitis B virus (HBV) in cell culture. By modification of the shells with a synthetic monoclonal antibody that binds to the HBV envelope, the effective neutralization potency per antibody is increased by approximately 100 times compared to using free antibodies. The improvements in neutralizing the virus are attributed to two factors: first, the shells act as a physical barrier that blocks the virus from interacting with host cells; second, the multivalent binding of the antibodies inside the shells lead to stronger attachment to the trapped virus, a phenomenon known as avidity. Pre-incubation of shells with HBV and simultaneous addition of both components separately to cells lead to comparable levels of neutralization, indicating rapid trapping of the virions by the shells. Our study highlights the potential of the DNA shell system to rationally create antivirals using components that, when used individually, show little to no antiviral effectiveness.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Dna Origami ; Antivirals ; Hepatitis B Virus ; In Vitro Neutralization ; Viral Blocking
ISSN (print) / ISBN
1944-8244
e-ISSN
1944-8252
Zeitschrift
ACS applied materials & interfaces
Quellenangaben
Band: 16,
Heft: 20,
Seiten: 25836-25842
Verlag
ACS
Verlagsort
Washington, DC
Nichtpatentliteratur
Publikationen
Institut(e)
Institute of Virology (VIRO)