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Machine learning integrative approaches to advance computational immunology.
Genome Med. 16:80 (2024)
The study of immunology, traditionally reliant on proteomics to evaluate individual immune cells, has been revolutionized by single-cell RNA sequencing. Computational immunologists play a crucial role in analysing these datasets, moving beyond traditional protein marker identification to encompass a more detailed view of cellular phenotypes and their functional roles. Recent technological advancements allow the simultaneous measurements of multiple cellular components-transcriptome, proteome, chromatin, epigenetic modifications and metabolites-within single cells, including in spatial contexts within tissues. This has led to the generation of complex multiscale datasets that can include multimodal measurements from the same cells or a mix of paired and unpaired modalities. Modern machine learning (ML) techniques allow for the integration of multiple "omics" data without the need for extensive independent modelling of each modality. This review focuses on recent advancements in ML integrative approaches applied to immunological studies. We highlight the importance of these methods in creating a unified representation of multiscale data collections, particularly for single-cell and spatial profiling technologies. Finally, we discuss the challenges of these holistic approaches and how they will be instrumental in the development of a common coordinate framework for multiscale studies, thereby accelerating research and enabling discoveries in the computational immunology field.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Cell-receptor Repertoires; Gene-expression; Rna-seq; Drug Response; Cytometry; Cancer; Omics; Deconvolution; Landscape; Proteins
ISSN (print) / ISBN
1756-994X
e-ISSN
1756-994X
Zeitschrift
Genome Medicine
Quellenangaben
Band: 16,
Heft: 1,
Artikelnummer: 80
Verlag
BioMed Central
Verlagsort
Campus, 4 Crinan St, London N1 9xw, England
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Computational Biology (ICB)
Förderungen
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)