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Herder, C.* ; Thorand, B. ; Strom, A.* ; Rathmann, W.* ; Heier, M. ; Koenig, W.* ; Morrison, H.* ; Ziegler, D.* ; Roden, M.* ; Peters, A. ; Bönhof, G.J.* ; Maalmi, H.*

Associations between multiple neurological biomarkers and distal sensorimotor polyneuropathy: KORA F4/FF4 study.

Diabetes Metab. Res. Rev. 40:e3807 (2024)
DOI PMC
Creative Commons Lizenzvertrag
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
AIMS: The aim of this study was to assess associations between neurological biomarkers and distal sensorimotor polyneuropathy (DSPN). MATERIALS AND METHODS: Cross-sectional analyses were based on 1032 participants aged 61-82 years from the population-based KORA F4 survey, 177 of whom had DSPN at baseline. The prevalence of type 2 diabetes was 20%. Prospective analyses used data from 505 participants without DSPN at baseline, of whom 125 had developed DSPN until the KORA FF4 survey. DSPN was defined based on the examination part of the Michigan Neuropathy Screening Instrument. Serum levels of neurological biomarkers were measured using proximity extension assay technology. Associations between 88 biomarkers and prevalent or incident DSPN were estimated using Poisson regression with robust error variance and are expressed as risk ratios (RR) and 95% CI per 1-SD increase. Results were adjusted for multiple confounders and multiple testing using the Benjamini-Hochberg procedure. RESULTS: Higher serum levels of CTSC (cathepsin C; RR [95% CI] 1.23 (1.08; 1.39), pB-H = 0.044) and PDGFRα (platelet-derived growth factor receptor A; RR [95% CI] 1.21 (1.08; 1.35), pB-H = 0.044) were associated with prevalent DSPN in the total study sample. CDH3, JAM-B, LAYN, RGMA and SCARA5 were positively associated with DSPN in the diabetes subgroup, whereas GCP5 was positively associated with DSPN in people without diabetes (all pB-H for interaction <0.05). None of the biomarkers showed an association with incident DSPN (all pB-H>0.05). CONCLUSIONS: This study identified multiple novel associations between neurological biomarkers and prevalent DSPN, which may be attributable to functions of these proteins in neuroinflammation, neural development and myelination.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Biomarker ; Cathepsin ; Distal Sensorimotor Polyneuropathy ; Myelination ; Neuroinflammation ; Platelet‐derived Growth Factor Receptor; Growth-factor Receptor; Progression; Population; Beta
ISSN (print) / ISBN 1520-7552
e-ISSN 1520-7560
Zeitschrift Diabetes/Metabolism Research and Reviews
Quellenangaben Band: 40, Heft: 5, Seiten: , Artikelnummer: e3807 Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Förderungen Bundesministerium für Gesundheit
European Foundation for the Study of Diabetes
Deutsches Zentrum fur Diabetesforschung
Bundesministerium für Bildung und Forschung
Ministerium fur Kultur und Wissenschaft des Landes Nordrhein-Westfalen
Land Bayern