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Couacault, P. ; Avella, D.* ; Londoño-Osorio, S.* ; Lorenzo, A.S.* ; Gradillas, A.* ; Kärkkäinen, O.* ; Want, E.* ; Witting, M.

Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives.

Anal. Sci. Adv. 5:e2400002 (2024)
DOI PMC
Creative Commons Lizenzvertrag
Blood microsampling (BµS) offers an alternative to conventional methods that use plasma or serum for profiling human health, being minimally invasive and cost effective, especially beneficial for vulnerable populations. We present a non-systematic review that offers a synopsis of the analytical methods, applications and perspectives related to dry blood microsampling in targeted and untargeted metabolomics and lipidomics research in the years 2022 and 2023. BµS shows potential in neonatal and paediatric studies, therapeutic drug monitoring, metabolite screening, biomarker research, sports supervision, clinical disorders studies and forensic toxicology. Notably, dried blood spots and volumetric absorptive microsampling options have been more extensively studied than other volumetric technologies. Therefore, we suggest that a further investigation and application of the volumetric technologies will contribute to the use of BµS as an alternative to conventional methods. Conversely, we support the idea that harmonisation of the analytical methods when using BµS would have a positive impact on its implementation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Blood Microsampling ; Dried Blood ; Lc–ms Analysis ; Lipidomics ; Metabolomics ; Targeted And Untargeted; Spots
ISSN (print) / ISBN 2628-5452
e-ISSN 2628-5452
Zeitschrift Analytical Science Advances
Quellenangaben Band: 5, Heft: 5-6, Seiten: , Artikelnummer: e2400002 Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CF Metabolomics & Proteomics (CF-MPC)
Förderungen Marie Curie Actions
European Union
HORIZON EUROPE Marie Sklodowska-Curie Actions