Couacault, P. ; Avella, D.* ; Londoño-Osorio, S.* ; Lorenzo, A.S.* ; Gradillas, A.* ; Kärkkäinen, O.* ; Want, E.* ; Witting, M.
Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives.
Anal. Sci. Adv. 5:e2400002 (2024)
Blood microsampling (BµS) offers an alternative to conventional methods that use plasma or serum for profiling human health, being minimally invasive and cost effective, especially beneficial for vulnerable populations. We present a non-systematic review that offers a synopsis of the analytical methods, applications and perspectives related to dry blood microsampling in targeted and untargeted metabolomics and lipidomics research in the years 2022 and 2023. BµS shows potential in neonatal and paediatric studies, therapeutic drug monitoring, metabolite screening, biomarker research, sports supervision, clinical disorders studies and forensic toxicology. Notably, dried blood spots and volumetric absorptive microsampling options have been more extensively studied than other volumetric technologies. Therefore, we suggest that a further investigation and application of the volumetric technologies will contribute to the use of BµS as an alternative to conventional methods. Conversely, we support the idea that harmonisation of the analytical methods when using BµS would have a positive impact on its implementation.
Impact Factor
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Times Cited
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Cited By
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Blood Microsampling ; Dried Blood ; Lc–ms Analysis ; Lipidomics ; Metabolomics ; Targeted And Untargeted; Spots
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2024
Prepublished im Jahr
0
HGF-Berichtsjahr
2024
ISSN (print) / ISBN
2628-5452
e-ISSN
2628-5452
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 5,
Heft: 5-6,
Seiten: ,
Artikelnummer: e2400002
Supplement: ,
Reihe
Verlag
Wiley
Verlagsort
111 River St, Hoboken 07030-5774, Nj Usa
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e)
A-630710-001
Förderungen
Marie Curie Actions
European Union
HORIZON EUROPE Marie Sklodowska-Curie Actions
Copyright
Erfassungsdatum
2024-06-25