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MRI-based adrenal gland volume is associated with cardiovascular alterations in individuals without prior cardiovascular disease.
Sci. Rep. 14:14664 (2024)
Aim of this study was to analyse the associations of cardiovascular health and adrenal gland volume as a rather new imaging biomarker of chronic hypothalamic-pituitary-adrenal (HPA) axis activation. The study population originates from the KORA population-based cross-sectional prospective cohort. 400 participants without known cardiovascular disease underwent a whole-body MRI. Manual segmentation of adrenal glands was performed on VIBE-Dixon gradient-echo sequence. MRI based evaluation of cardiac parameters was achieved semi-automatically. Cardiometabolic risk factors were obtained through standardized interviews and medical examination. Univariate and multivariate associations were derived. Bi-directional causal mediation analysis was performed. 351 participants were eligible for analysis (56 ± 9.1 years, male 58.7%). In multivariate analysis, significant associations were observed between adrenal gland volume and hypertension (outcome hypertension: Odds Ratio = 1.11, 95% CI [1.01, 1.21], p = 0.028), left ventricular remodelling index (LVRI) (outcome LVRI: β = 0.01, 95% CI [0.00, 0.02], p = 0.011), and left ventricular (LV) wall thickness (outcome LV wall thickness: β = 0.06, 95% CI [0.02, 0.09], p = 0.005). In bi-directional causal mediation analysis adrenal gland volume had a borderline significant mediating effect on the association between hypertension and LVRI (p = 0.052) as well as wall thickness (p = 0.054). MRI-based assessment of adrenal gland enlargement is associated with hypertension and LV remodelling. Adrenal gland volume may serve as an indirect cardiovascular imaging biomarker.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Myocardial-infarction; Hair Cortisol; Glucocorticoids; Population; Kora
ISSN (print) / ISBN
2045-2322
e-ISSN
2045-2322
Zeitschrift
Scientific Reports
Quellenangaben
Band: 14,
Heft: 1,
Artikelnummer: 14664
Verlag
Nature Publishing Group
Verlagsort
London
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology II (EPI2)
Förderungen
German Center for Diabetes Research (DZD e.V., Neuherberg, Germany)
German Center for Cardiovascular Disease Research (DZHK, Berlin, Germany)
German Research Foundation (DFG, Bonn, Germany)
State of Bavaria
German Federal Ministry of Education and Research (BMBF)
Helmholtz Zentrum Munchen - German Research Center for Environmental Health
Projekt DEAL
German Center for Cardiovascular Disease Research (DZHK, Berlin, Germany)
German Research Foundation (DFG, Bonn, Germany)
State of Bavaria
German Federal Ministry of Education and Research (BMBF)
Helmholtz Zentrum Munchen - German Research Center for Environmental Health
Projekt DEAL