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Teboul, L.* ; Amos-Landgraf, J.* ; Benavides, F.J.* ; Birling, M.C.* ; Brown, S.D.M.* ; Bryda, E.* ; Bunton-Stasyshyn, R.K.A.* ; Chin, H.J.G.* ; Crispo, M.* ; Delerue, F.* ; Dobbie, M.* ; Franklin, C.L.* ; Füchtbauer, E.M.* ; Gao, X.* ; Golzio, C.* ; Haffner, R.* ; Hérault, Y.* ; Hrabě de Angelis, M. ; Lloyd, K.C.K.* ; Magnuson, T.R.* ; Montoliu, L.* ; Murray, S.A.* ; Nam, K.H.* ; Nutter, L.M.J.* ; Pailhoux, E.* ; Pardo Manuel de Villena, F.* ; Peterson, K.* ; Reinholdt, L.* ; Sedlacek, R.* ; Seong, J.K.* ; Shiroishi, T.* ; Smith, C.* ; Takeo, T.* ; Tinsley, L.* ; Vilotte, J.L.* ; Warming, S.* ; Wells, S.* ; Whitelaw, C.B.* ; Yoshiki, A.* ; Pavlovic, G.*

Improving laboratory animal genetic reporting: LAG-R guidelines.

Nat. Commun. 15:5574 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guidelines outline documentation standards for laboratory animals in experiments, but genetic information is often incomplete. To remedy this, we propose the Laboratory Animal Genetic Reporting (LAG-R) framework. LAG-R aims to document animals' genetic makeup in scientific publications, providing essential details for replication and appropriate model use. While verifying complete genetic compositions may be impractical, better reporting and validation efforts enhance reliability of research. LAG-R standardization will bolster reproducibility, peer review, and overall scientific rigor.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Mutation; Reproducibility; Husbandry; Phenotype; Scale; Mice
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 15, Heft: 1, Seiten: , Artikelnummer: 5574 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Förderungen Ministry of Education, Youth and Sports of the Czech Republic
Czech Academy of Sciences
National Science and Technology Council, Taiwan
Neogen Inc., Lincoln, NE

NIH