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Frielitz-Wagner, I.V.* ; Mattutat, J.* ; Frielitz, F.S.* ; Scheuermann, K.* ; Gesing, J.* ; Marheineke, D.* ; Löffler, D.S.* ; Kiess, W.* ; Körner, A.

Diurnal rythm of Nampt is gender and weight dependent.

Obes. Res. Clin. Pract. 18, 181-188 (2024)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
RESEARCH AIM: Nicotinamide phosphoribosyltransferase (Nampt) is an adipocytokine that is elevated in obesity, type 2 diabetes and increased levels are associated with inflammatory processes. Nampt serum concentrations have been suggested to follow a diurnal rhythm peaking in the afternoon in lean males. However, no data exists regarding the effects of gender and body weight. MATERIAL AND METHODS: We measured Nampt serum levels over 24 h in a cohort of healthy individuals living with either normal weight or obesity. Furthermore, effects of meals, oral glucose tolerance test and physical exercise on Nampt concentrations were evaluated. Correlation analyses to other hormonal- and lab parameters and anthropometric measurements were performed. RESULTS: Nampt showed a diurnal rhythm with increased levels at daytime and a peak in the early afternoon. This diurnal rhythm was significant for all groups but obese males. The Nampt amplitude, measured both relatively and absolutely, was significantly higher in females than in males. Meals did not influence Nampt serum levels, whereas physical exercise and an OGTT did significantly influence Nampt serum levels. CONCLUSION: In conclusion, we found gender specific differences in Nampt amplitude and coefficient variation with both being higher in females. The circadian rhythm of Nampt was independent of gender in healthy lean individuals, whereas it was disturbed in men with obesity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Diurnal Rhythm ; Nampt ; Obesity; Plasma Visfatin Concentrations; Adipokine; Glucose; Obese; Fat
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1871-403X
e-ISSN 1878-0318
Zeitschrift Obesity Research and Clinical Practice
Quellenangaben Band: 18, Heft: 3, Seiten: 181-188 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 125 London Wall, London, England
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-506503-001
Förderungen Integrated Research and Treatment Centre (IFB) Adiposity Diseases
Federal Ministry of Education and Research (BMBF) , Germany
European Regional Development Fund (ERFD) by means of the Free State of Saxony
LIFE (Leipzig Research Center for Civilization Diseases, Universitat Leipzig) - European Union
German Research Foundation (DFG)
DOI 10.1016/j.orcp.2024.06.005
WOS ID 001265941100001
Scopus ID 85197444230
PubMed ID 38960771
Erfassungsdatum 2024-07-24
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