PuSH - Publikationsserver des Helmholtz Zentrums München

Schulze, M.B.* ; Stefan, N.

Metabolically healthy obesity: From epidemiology and mechanisms to clinical implications.

Nat. Rev. Endocrinol., DOI: 10.1038/s41574-024-01008-5 (2024)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The concept of metabolic health, particularly in obesity, has attracted a lot of attention in the scientific community, and is being increasingly used to determine the risk of cardiovascular diseases and diabetes mellitus-related complications. This Review assesses the current understanding of metabolically healthy obesity (MHO). First, we present the historical evolution of the concept. Second, we discuss the evidence for and against its existence, the usage of different definitions of MHO over the years and the efforts made to provide novel definitions of MHO. Third, we highlight epidemiological data with regard to cardiovascular risk in MHO, which is estimated to be moderately elevated using widely used definitions of MHO when compared with individuals with metabolically healthy normal weight, but potentially not elevated using a novel definition of MHO. Fourth, we discuss novel findings about the physiological mechanisms involved in MHO and how such knowledge helps to identify and characterize both people with MHO and those with metabolically unhealthy normal weight. Finally, we address how the concept of MHO can be used for risk stratification and treatment in clinical practice.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Body-mass Index; Coronary-heart-disease; Cardiovascular-disease; Adipose-tissue; Normal-weight; Risk; Metaanalysis; Individuals; People; Identification
ISSN (print) / ISBN 1759-5029
e-ISSN 1759-5037
Zeitschrift Nature Reviews - Endocrinology
Verlag Nature Publishing Group
Verlagsort New York, NY
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy (SOPHIA) project
German Centre of Diabetes Research (DZD)
German Federal Ministry of Education and Research (BMBF)