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Wang, T.* ; Sharma, A.K.* ; Wu, C.* ; Maushart, C.I.* ; Ghosh, A.* ; Yang, W.* ; Stefanicka, P.* ; Kovanicova, Z.* ; Ukropec, J.* ; Zhang, J.* ; Arnold, M.* ; Klug, M.* ; de Bock, K.* ; Schneider, U.* ; Popescu, C.* ; Zheng, B.* ; Ding, L.* ; Long, F.* ; Dewal, R.S.* ; Moser, C.* ; Sun, W.* ; Dong, H.* ; Takes, M.* ; Suelberg, D.* ; Mameghani, A.* ; Nocito, A.* ; Zech, C.J.* ; Chirindel, A.* ; Wild, D.* ; Burger, I.A.* ; Schön, M.R.* ; Dietrich, A.* ; Gao, M.* ; Heine, M.* ; Sun, Y.* ; Vargas-Castillo, A.* ; Søberg, S.* ; Scheele, C.* ; Balaz, M.* ; Blüher, M. ; Betz, M.J.* ; Spiegelman, B.M.* ; Wolfrum, C.*

Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes.

Cell Metab. 36, DOI: 10.1016/j.cmet.2024.07.005 (2024)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Adipose tissue can recruit catabolic adipocytes that utilize chemical energy to dissipate heat. This process occurs either by uncoupled respiration through uncoupling protein 1 (UCP1) or by utilizing ATP-dependent futile cycles (FCs). However, it remains unclear how these pathways coexist since both processes rely on the mitochondrial membrane potential. Utilizing single-nucleus RNA sequencing to deconvolute the heterogeneity of subcutaneous adipose tissue in mice and humans, we identify at least 2 distinct subpopulations of beige adipocytes: FC-adipocytes and UCP1-beige adipocytes. Importantly, we demonstrate that the FC-adipocyte subpopulation is highly metabolically active and utilizes FCs to dissipate energy, thus contributing to thermogenesis independent of Ucp1. Furthermore, FC-adipocytes are important drivers of systemic energy homeostasis and linked to glucose metabolism and obesity resistance in humans. Taken together, our findings identify a noncanonical thermogenic adipocyte subpopulation, which could be an important regulator of energy homeostasis in mammals.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Energy Homeostasis ; Futile Cycling ; Human Metabolism ; Single-nucleus Rna Sequencing ; Thermogenesis
ISSN (print) / ISBN 1550-4131
e-ISSN 1932-7420
Zeitschrift Cell Metabolism
Quellenangaben Band: 36 Heft: , Seiten: , Artikelnummer: , Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)