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Mi, B.* ; Xiong, Y.* ; Knoedler, S. ; Alfertshofer, M.* ; Panayi, A.C.* ; Wang, H.* ; Lin, S.* ; Li, G.* ; Liu, G.*

Ageing-related bone and immunity changes: Insights into the complex interplay between the skeleton and the immune system.

Bone Res. 12:42 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues, including the skeletal and immune systems. Recent studies have elucidated the intricate bidirectional interactions between these two systems. In this review, we provide a comprehensive synthesis of molecular mechanisms of cell ageing. We further discuss how age-related skeletal changes influence the immune system and the consequent impact of immune system alterations on the skeletal system. Finally, we highlight the clinical implications of these findings and propose potential strategies to promote healthy ageing and reduce pathologic deterioration of both the skeletal and immune systems.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Hematopoietic Stem-cells; Regulatory T-cells; Senescent Cells; Osteoblast Differentiation; Secretory Phenotype; Aged Mice; Marrow; Impact; Osteogenesis; Osteoporosis
ISSN (print) / ISBN 2095-4700
e-ISSN 2095-6231
Zeitschrift Bone Research
Quellenangaben Band: 12, Heft: 1, Seiten: , Artikelnummer: 42 Supplement: ,
Verlag Springer
Verlagsort Campus, 4 Crinan St, London, N1 9xw, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology and Medicine (IRBM)
Förderungen CUHK
Research Grants Council of the Hong Kong Special Administrative Region, China
University Grants Committee
Wuhan Science and Technology Bureau
National Key R&D Program of China