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Martinez Lumbreras, S. ; Morguet, C. ; Sattler, M.

Dynamic interactions drive early spliceosome assembly.

Curr. Opin. Struct. Biol. 88:102907 (2024)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Splicing is a critical processing step during pre-mRNA maturation in eukaryotes. The correct selection of splice sites during the early steps of spliceosome assembly is highly important and crucial for the regulation of alternative splicing. Splice site recognition and alternative splicing depend on cis-regulatory sequence elements in the RNA and trans-acting splicing factors that recognize these elements and crosstalk with the canonical splicing machinery. Structural mechanisms involving early spliceosome complexes are governed by dynamic RNA structures, protein-RNA interactions and conformational flexibility of multidomain RNA binding proteins. Here, we highlight structural studies and integrative structural biology approaches, which provide complementary information from cryo-EM, NMR, small angle scattering, and X-ray crystallography to elucidate mechanisms in the regulation of early spliceosome assembly and quality control, highlighting the role of conformational dynamics.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Site Recognition; Protein Recognition; Splicing Regulation; Structural Basis; Rna Recognition; Snrnp; Exon; Association; Regulator; Selection
ISSN (print) / ISBN 0959-440X
e-ISSN 1879-033X
Zeitschrift Current Opinion in Structural Biology
Quellenangaben Band: 88, Heft: , Seiten: , Artikelnummer: 102907 Supplement: ,
Verlag Elsevier
Verlagsort 84 Theobalds Rd, London Wc1x 8rr, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Structural Biology (STB)
Förderungen European Union
Deutsche Forschungsgemeinschaft