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Kramer, J.* ; Aires, R.* ; Keeley, S.D.* ; Schröder, T.A.* ; Lauer, G.M.* ; Sandoval-Guzmán, T.

Axolotl mandible regeneration occurs through mechanical gap closure and a shared regenerative program with the limb.

Dis. Model. Mech. 17:dmm050743 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The mandible plays an essential part in human life and, thus, defects in this structure can dramatically impair the quality of life in patients. Axolotls, unlike humans, are capable of regenerating their lower jaws; however, the underlying mechanisms and their similarity to those in limb regeneration are unknown. In this work, we used morphological, histological, and transcriptomic approaches to analyze the regeneration of lateral resection defects in the axolotl mandible. We found that this structure can regenerate all missing tissues in 90 days through gap minimization, blastema formation, and finally tissue growth, differentiation, and integration. Moreover, transcriptomic comparisons of regenerating mandibles and limbs showed that they share molecular phases of regeneration, that these similarities peak during blastema stages, and that mandible regeneration occurs at a slower pacing. Altogether, our study demonstrates the existence of a shared regenerative program used in two different regenerating body structures with different embryonic origins in the axolotl, and contributes to our understanding of the minimum requirements for a successful regeneration in vertebrates, bringing us closer to understand similar lesions in human mandibles.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Axolotl ; Cartilage ; Gap Minimization ; Jaw ; Limb ; Regeneration; Dental Lamina; Lower Jaws; Matrix-metalloproteinase; Salamander; Reconstruction; Transcriptome; Choreography; Fractures; Patterns; Origin
ISSN (print) / ISBN 1754-8403
e-ISSN 1754-8411
Zeitschrift Disease Models and Mechanisms
Quellenangaben Band: 17, Heft: 9, Seiten: , Artikelnummer: dmm050743 Supplement: ,
Verlag Company of Biologists
Verlagsort Bidder Building, Station Rd, Histon, Cambridge Cb24 9lf, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)
Förderungen Technische Universitat Dresden
Sachsische Landesbibliothek - Staats-und Universitatsbibliothek (SLUB) Dresden
Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB) graduate program
Deutsche Forschungsgemeinschaft (DFG) Eigene Stelle Grant
Alexander von Humboldt-Stiftung research fellowship