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Aziz, K.* ; Koffler, D.* ; Vassantachart, A.* ; Rattani, A.* ; Ankrah, N.K.* ; Gogineni, E.* ; Andraos, T.Y.* ; Sahgal, A.* ; Vellayappan, B.* ; Dunne, E.M.* ; Siva, S.* ; Moraes, F.Y.* ; Guckenberger, M.* ; Lubelski, D.* ; Chao, S.* ; Combs, S.E. ; Chang, E.L.* ; Amin, A.G.* ; Foote, M.* ; Gibbs, I.* ; Kim, M.* ; Palmer, J.* ; Lo, S.S.* ; Redmond, K.J.*

Radiosurgery society case-based guide to stereotactic body radiation therapy for challenging cases of spinal metastases.

Pract. Radiat. Oncol. 15, 54-68 (2024)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
PURPOSE: Spinal stereotactic body radiation therapy (SBRT) has become the standard of care in management of patients with limited sites of metastatic disease, radio-resistant histologies, painful vertebral metastases with long life expectancy and cases of reirradiation. Our case-based guidelines aim to assist radiation oncologists in the appropriate utilization of SBRT for common, yet challenging, cases of spinal metastases. MATERIALS AND METHODS: Cases were selected to include scenarios of large volume sacral disease with nerve entrapment, medically inoperable disease abutting the thecal sac, and local failure after prior SBRT. Relevant literature was reviewed, and areas requiring further investigation were discussed to offer a framework for evidence-based clinical practice. RESULTS: Spinal SBRT can be effectively delivered in challenging cases following multidisciplinary discussion by utilizing a methodical approach to patient selection, appropriate dose selection, and adherence to evidence-based dose constraints. CONCLUSIONS: The Radiosurgery Society's case-based practice review offers guidance to practicing physicians treating technically challenging SBRT candidate patients with spinal metastases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Vertebral Compression Fracture; Oligometastatic Disease; Consensus Guidelines; Sacral Metastases; Phase 2/3; Radiotherapy; Outcomes; Cancer; Recommendations; Oncology
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1879-8500
e-ISSN 1879-8519
Zeitschrift Practical Radiation Oncology
Quellenangaben Band: 15, Heft: 1, Seiten: 54-68 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501300-001
Förderungen Pharmaceuticals
Merck Sharp Dohme
Roche Pharmaceuticals
American Society of Radiation Oncology Science Council
Advanced Radiotherapy Techniques committee of the International Association for the Study of Lung Cancer
DOI 10.1016/j.prro.2024.08.004
WOS ID 001400980900001
Scopus ID 85205666936
PubMed ID 39233007
Erfassungsdatum 2024-10-15
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