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Saucy, A.* ; Coloma, F.* ; Olmos, S.* ; Åström, C.* ; Blay, N.* ; Boer, J.M.A.* ; Dadvand, P.* ; de Bont, J.* ; de Cid, R.* ; de Hoogh, K.* ; Dimakopoulou, K.* ; Gehring, U.* ; Huss, A.* ; Ibi, D.* ; Katsouyanni, K.* ; Koppelman, G.* ; Ljungman, P.* ; Melén, E.* ; Nieuwenhuijsen, M.* ; Nobile, F.* ; Peters, A. ; Pickford, R. ; Vermeulen, R.* ; Vienneau, D.* ; Vlaanderen, J.* ; Wolf, K. ; Yu, Z.* ; Samoli, E.* ; Stafoggia, M.* ; Tonne, C.*

Socioeconomic inequalities in the external exposome in European cohorts: The EXPANSE Project.

Environ. Sci. Technol. 58, 16248-16257 (2024)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Socioeconomic inequalities in the exposome have been found to be complex and highly context-specific, but studies have not been conducted in large population-wide cohorts from multiple countries. This study aims to examine the external exposome, encompassing individual and environmental factors influencing health over the life course, and to perform dimension reduction to derive interpretable characterization of the external exposome for multicountry epidemiological studies. Analyzing data from over 25 million individuals across seven European countries including 12 administrative and traditional cohorts, we utilized domain-specific principal component analysis (PCA) to define the external exposome, focusing on air pollution, the built environment, and air temperature. We conducted linear regression to estimate the association between individual- and area-level socioeconomic position and each domain of the external exposome. Consistent exposure patterns were observed within countries, indicating the representativeness of traditional cohorts for air pollution and the built environment. However, cohorts with limited geographical coverage and Southern European countries displayed lower temperature variability, especially in the cold season, compared to Northern European countries and cohorts including a wide range of urban and rural areas. The individual- and area-level socioeconomic determinants (i.e., education, income, and unemployment rate) of the urban exposome exhibited significant variability across the European region, with area-level indicators showing stronger associations than individual variables. While the PCA approach facilitated common interpretations of the external exposome for air pollution and the built environment, it was less effective for air temperature. The diverse socioeconomic determinants suggest regional variations in environmental health inequities, emphasizing the need for targeted interventions across European countries.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter European Cohorts ; Environmental Health Equity ; External Exposome ; Socioeconomic Determinants
ISSN (print) / ISBN 0013-936X
e-ISSN 1520-5851
Zeitschrift Environmental Science & Technology
Quellenangaben Band: 58, Heft: 37, Seiten: 16248-16257 Artikelnummer: , Supplement: ,
Verlag ACS
Verlagsort Washington, DC
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Förderungen Umea University
Netherlands Organisation for Health Research and Development (ZonMw) within the Electromagnetic Fields and Health Research program
National Institute for Public Health and the Environment
Netherlands Ministry of Health, Welfare, and Sport
Netherlands Ministry of Spatial Planning, Housing, and the Environment
Dutch Research Council (NWO)
Netherlands Organisation for Health Research and Development
Dutch Lung Foundation
Swiss National Science Foundation
Generalitat de Catalunya through the CERCA Program
Spanish Ministry of Science and Innovation and State Research Agency through the "Centro de Excelencia Severo Ochoa 2019-2023" Program
Netherlands Organisation for Scientific Research (NWO)
Dutch Ministry of Education, Culture, and Science
Swedish Research Council
World Cancer Research Fund (WCRF)
ZonMw (Netherlands Organisation for Health Research and Development)
Dutch Cancer Society
Dutch Ministry of Economic Affairs
Dutch Ministry of Public Health, Welfare, and Sports
Europe against Cancer Program of the European Commission (DG-SANCO)
Spanish National Grant
Ministry of Health of the Generalitat of Catalunya
Accion de Dinamizacion del ISCIII-MINECO
State of Bavaria
German Federal Ministry of Education and Research (BMBF)
Helmholtz Zentrum Munchen-German Research Center for Environmental Health
Swedish Heart-Lung Foundation, Region Stockholm
European Union