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Grimm, C.* ; Duss, S.N.* ; Privitera, M.* ; Munn, B.R.* ; Karalis, N.* ; Frässle, S.* ; Wilhelm, M.* ; Patriarchi, T.* ; Razansky, D. ; Wenderoth, N.* ; Shine, J.M.* ; Bohacek, J.* ; Zerbi, V.*

Tonic and burst-like locus coeruleus stimulation distinctly shift network activity across the cortical hierarchy.

Nat. Neurosci., DOI: 10.1038/s41593-024-01755-8 (2024)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Noradrenaline (NA) release from the locus coeruleus (LC) changes activity and connectivity in neuronal networks across the brain, modulating multiple behavioral states. NA release is mediated by both tonic and burst-like LC activity. However, it is unknown whether the functional changes in target areas depend on these firing patterns. Using optogenetics, photometry, electrophysiology and functional magnetic resonance imaging in mice, we show that tonic and burst-like LC firing patterns elicit brain responses that hinge on their distinct NA release dynamics. During moderate tonic LC activation, NA release engages regions associated with associative processing, while burst-like stimulation biases the brain toward sensory processing. These activation patterns locally couple with increased astrocytic and inhibitory activity and change the brain's topological configuration in line with the hierarchical organization of the cerebral cortex. Together, these findings reveal how the LC-NA system achieves a nuanced regulation of global circuit operations.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Noradrenergic System; Neuronal-activity; Hemodynamic-response; Ceruleus Neurons; Activation; Modulation; Monkey; State; Performance; Attention
ISSN (print) / ISBN 1097-6256
e-ISSN 1546-1726
Zeitschrift Nature Neuroscience
Verlag Nature Publishing Group
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Förderungen SNSF AMBIZIONE
Swiss National Science Foundation (SNSF)
ETH Zurich
SNSF
Swiss 3R Competence Center
Basel Research Centre for Child Health
Hochschulmedizin Zurich Flagship Project STRESS
National Health and Medical Research Council
ETH