PuSH - Publikationsserver des Helmholtz Zentrums München

Heinrich, J. ; Brüske, I. ; Cramer, C.* ; Hoffmann, U.* ; Schnappinger, M. ; Schaaf, B.* ; von Berg, A.* ; Berdel, D.* ; Krämer, U.* ; Lehmann, I.* ; Herbarth, O.* ; Borte, M.* ; Grubl, A.* ; Bauer, C.P.* ; Beckmann, C.* ; Behrendt, H.* ; Ring, J.* ; Koletzko, S.*

GINIplus und LISAplus. Design und ausgewählte Ergebnisse zweier deutscher Geburtskohorten zum natürlichen Verlauf atopischer Erkrankungen sowie deren Determinanten.

GINIplus and LISAplus - Design and selected results of two German birth cohorts about natural course of atopic diseases and their determinants.

Allergologie 35, 20-31 (2012)
DOI PMC
The increasing prevalence of asthma, hay fever and allergic sensitization in Western Germany after division in 1949 and the rapid increase in East German children after re-unification in 1990 are strong indications for the role of life-style and/or environmental factors for development of atopic diseases. Obviously the perinatal period is crucial for priming the immune system. Therefore, explorations of determinants of atopic diseases need pregnancy or birth cohorts as most appropriate epidemiological study designs. This review presents the design and selected results of the two German birth cohorts GINIplus and LISAplus. GINIplus and LISAplus recruited 5.991 and 3.097 healthy, term newborns from Munich, Wesel, Leipzig and Bad Honnef. Approximatly 55% could be followed for the first 10 years. We analyzed the natural course of atopic diseases and the role of life-style, environmental and genetic factors for disease onset, intermediate phenotypes and for genes involved in detoxification and oxidative stress. The results of these two large birth cohorts contributed substantially to the understanding of atopic diseases and its determinants.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter allergy; East-West-Germany; lifestyle; environmental factors; genes; epidemiology; children
ISSN (print) / ISBN 0344-5062
e-ISSN 0344-5062
Zeitschrift Allergologie
Quellenangaben Band: 35, Heft: 1, Seiten: 20-31 Artikelnummer: , Supplement: ,
Verlag Dustri
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)