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He, Y.* ; Zhang, M.* ; Ju, Y.* ; Yu, Z.* ; Lv, D.* ; Sun, H.* ; Yuan, W.* ; He, F.* ; Zhang, J.* ; Li, H.* ; Li, J.* ; Wang-Sattler, R. ; Li, Y.* ; Zhang, G.* ; Xie, L.*

dbDEPC 2.0: Updated database of differentially expressed proteins in human cancers.

Nucleic Acids Res. 40, D964-D971 (2012)
Verlagsversion Volltext DOI PMC
Open Access Gold
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A large amount of differentially expressed proteins (DEPs) have been identified in various cancer proteomics experiments, curation and annotation of these proteins are important in deciphering their roles in oncogenesis and tumor progression, and may further help to discover potential protein biomarkers for clinical applications. In 2009, we published the first database of DEPs in human cancers (dbDEPCs). In this updated version of 2011, dbDEPC 2.0 has more than doubly expanded to over 4000 protein entries, curated from 331 experiments across 20 types of human cancers. This resource allows researchers to search whether their interested proteins have been reported changing in certain cancers, to compare their own proteomic discovery with previous studies, to picture selected protein expression heatmap across multiple cancers and to relate protein expression changes with aberrance in other genetic level. New important developments include addition of experiment design information, advanced filter tools for customer-specified analysis and a network analysis tool. We expect dbDEPC 2.0 to be a much more powerful tool than it was in its first release and can serve as reference to both proteomics and cancer researchers.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Proteomics; Pathways; Genes; Cells; Index; MYC
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0305-1048
e-ISSN 1362-4962
Zeitschrift Nucleic Acids Research
Quellenangaben Band: 40, Heft: DI, Seiten: D964-D971 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Molecular Epidemiology (AME)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504200-003
PubMed ID 22096234
DOI 10.1093/nar/gkr936
WOS ID WOS:000298601300145
Scopus ID 84862229602
Erfassungsdatum 2012-02-28
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