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Relationship of proteins and subclinical cardiovascular traits in the population-based LIFE-Adult study.
Atherosclerosis 398:118613 (2024)
Verlagsversion
DOI
PMC
BACKGROUND AND AIMS: Understanding molecular processes of the early phase of atherosclerotic cardiovascular disease conditions is of utmost importance for early prediction and intervention measures. METHODS: We measured 92 cardiovascular-disease-related proteins (Olink, Cardiovascular III) in 2024 elderly participants of the population-based LIFE-Adult study. We analysed the impact of 27 covariables on these proteins including blood counts, cardiovascular risk factors and life-style-related parameters. We also analysed protein associations with 13 subclinical cardiovascular traits comprising carotid intima media thickness, plaque burden, three modes of Vicorder-based pulse-wave velocities, ankle-brachial index and ECLIA-based N-terminal prohormone of brain natriuretic peptide (NT-proBNP). RESULTS: Estimated glomerular filtration rate, triglycerides and sex where the most relevant covariables explaining more than 1 % variance of 49, 22 and 20 proteins, respectively. A total of 43 proteins were significantly associated with at least one of the analysed subclinical cardiovascular traits. NT-pro-BNP, brachial-ankle pulse-wave velocity (baPWV) and parameters of carotid plaque burden accounted for the largest number of associations. Association overlaps were relatively sparse. Only growth/differentiation factor 15, low density lipoprotein receptor and interleukin-1 receptor type 2 are associated with these three different cardiovascular traits. We confirmed several literature findings and found yet unreported associations for carotid plaque presence (von-Willebrand factor, galectin 4), carotid intima-media thickness (carboxypeptidase A1 andB1), baPWV (cathepsin D) and NT-proBNP (cathepsin Z, low density lipoprotein receptor, neurogenic locus homolog protein 3, trem-like transcript 2). Sex-interaction effects were observed, e.g. for spondin-1 and growth/differentiation factor 15 likely regulated by androgen response elements. CONCLUSIONS: We extend the catalogue of proteome biomarkers possibly involved in early stages of cardiovascular disease pathologies providing targets for early risk prediction or intervention strategies.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Ankle-brachial Index ; Cardiovascular Risk Factors ; Carotid Intima Media Thickness ; Carotid Plaque ; Nt-pro-bnp ; Pulse Wave Velocity; Intima-media Thickness; Heart-failure; Artery-disease; Matrix Metalloproteinases; R/bioconductor Package; Imaging Biomarkers; Carotid-artery; Proteomics; Atherosclerosis; Associations
ISSN (print) / ISBN
0021-9150
e-ISSN
1879-1484
Zeitschrift
Atherosclerosis
Quellenangaben
Band: 398,
Artikelnummer: 118613
Verlag
Elsevier
Verlagsort
Amsterdam
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Förderungen
German Federal Ministry of Education and Research (BMBF)
Helmholtz Zentrum Munchen
HIMAG project "Serum proteome biomarkers as mediators of cardiometabolic disease development" of the Medical Faculty of the University Leipzig
Free State of Saxony within the framework of the excellence initiative
European Regional Development Fund (ERDF)
European Union
Leipzig Research Center for Civilization Diseases (LIFE)
Helmholtz Zentrum Munchen
HIMAG project "Serum proteome biomarkers as mediators of cardiometabolic disease development" of the Medical Faculty of the University Leipzig
Free State of Saxony within the framework of the excellence initiative
European Regional Development Fund (ERDF)
European Union
Leipzig Research Center for Civilization Diseases (LIFE)