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Quiescence and aging of melanocyte stem cells and a novel association with programmed death-ligand 1.
iScience 27:110908 (2024)
Cellular quiescence is a reversible and tightly regulated stem cell function essential for healthy aging. However, the elements that control quiescence during aging remain poorly defined. Using melanocyte stem cells (McSCs), we find that stem cell quiescence is neither passive nor static. For example, gene expression profiling of the transition from proliferating melanoblasts to quiescent melanocyte stem cells reveals tissue-specific regulation of the immune checkpoint protein PD-L1. In vitro, quiescence assays demonstrate that PD-L1 expression is a physiological attribute of quiescence in this cell lineage and reinforces this cell state. In vivo, a subset of quiescent McSCs is marked by PD-L1. While the overall number of McSCs decreases with age, PD-L1+ McSCs appear resistant to depletion. This phenomenon coincides with an aged McSC pool that exhibits a deeper transcriptomic quiescence. We predict that quiescent PD-L1+ stem cells retained with age may serve as cellular targets for reactivation.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Functional Aspects Of Cell Biology ; Stem Cells Research; Outer Root Sheath; Hair Follicle; Pd-l1 Expression; Dna-synthesis; B7 Family; T-cells; Cancer; Growth; B7-h1; Age
ISSN (print) / ISBN
2589-0042
e-ISSN
2589-0042
Zeitschrift
iScience
Quellenangaben
Band: 27,
Heft: 10,
Artikelnummer: 110908
Verlag
Elsevier
Verlagsort
Amsterdam ; Bosten ; London ; New York ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes and Cancer (IDC)
Förderungen
NIH
National Cancer Institute
Science Alliance on Precision Medicine and Cancer Prevention by the German Federal Foreign Office
Machine Learning and Multiomics by the Bavaria California Technology Center
UAB Blazer Fellowship
National Human Genome Research Institute Intramural Research Program
Department of Biology and College of Arts of Science at the University of Alabama at Birmingham
UAB Faculty Development Grant Program
National Institute on Aging
National Cancer Institute
Science Alliance on Precision Medicine and Cancer Prevention by the German Federal Foreign Office
Machine Learning and Multiomics by the Bavaria California Technology Center
UAB Blazer Fellowship
National Human Genome Research Institute Intramural Research Program
Department of Biology and College of Arts of Science at the University of Alabama at Birmingham
UAB Faculty Development Grant Program
National Institute on Aging