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Palmer, J.W.* ; Villavicencio, K.M.* ; Idris, M.* ; Baranyk, I.J.* ; Polycarp, N.* ; Dawson, A.D.* ; Weddle, D.* ; Pavan, W.J.* ; Filipp, F.V. ; Harris, M.L.*

Quiescence and aging of melanocyte stem cells and a novel association with programmed death-ligand 1.

iScience 27:110908 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Cellular quiescence is a reversible and tightly regulated stem cell function essential for healthy aging. However, the elements that control quiescence during aging remain poorly defined. Using melanocyte stem cells (McSCs), we find that stem cell quiescence is neither passive nor static. For example, gene expression profiling of the transition from proliferating melanoblasts to quiescent melanocyte stem cells reveals tissue-specific regulation of the immune checkpoint protein PD-L1. In vitro, quiescence assays demonstrate that PD-L1 expression is a physiological attribute of quiescence in this cell lineage and reinforces this cell state. In vivo, a subset of quiescent McSCs is marked by PD-L1. While the overall number of McSCs decreases with age, PD-L1+ McSCs appear resistant to depletion. This phenomenon coincides with an aged McSC pool that exhibits a deeper transcriptomic quiescence. We predict that quiescent PD-L1+ stem cells retained with age may serve as cellular targets for reactivation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Functional Aspects Of Cell Biology ; Stem Cells Research; Outer Root Sheath; Hair Follicle; Pd-l1 Expression; Dna-synthesis; B7 Family; T-cells; Cancer; Growth; B7-h1; Age
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 2589-0042
e-ISSN 2589-0042
Zeitschrift iScience
Quellenangaben Band: 27, Heft: 10, Seiten: , Artikelnummer: 110908 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam ; Bosten ; London ; New York ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502500-001
Förderungen NIH
National Cancer Institute
Science Alliance on Precision Medicine and Cancer Prevention by the German Federal Foreign Office
Machine Learning and Multiomics by the Bavaria California Technology Center
UAB Blazer Fellowship
National Human Genome Research Institute Intramural Research Program
Department of Biology and College of Arts of Science at the University of Alabama at Birmingham
UAB Faculty Development Grant Program
National Institute on Aging
DOI 10.1016/j.isci.2024.110908
WOS ID 001320211000001
Scopus ID 85207771609
PubMed ID 39351197
Erfassungsdatum 2024-12-18
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