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Chen, B.* ; Yu, X.* ; Horvath-Diano, C.* ; Ortuño, M.J.* ; Tschöp, M.H. ; Jastreboff, A.M.* ; Schneeberger, M.*

GLP-1 programs the neurovascular landscape.

Cell Metab. 36, 2173-2189 (2024)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Readily available nutrient-rich foods exploit our inherent drive to overconsume, creating an environment of overnutrition. This transformative setting has led to persistent health issues, such as obesity and metabolic syndrome. The development of glucagon-like peptide-1 receptor (GLP-1R) agonists reveals our ability to pharmacologically manage weight and address metabolic conditions. Obesity is directly linked to chronic low-grade inflammation, connecting our metabolic environment to neurodegenerative diseases. GLP-1R agonism in curbing obesity, achieved by impacting appetite and addressing associated metabolic defects, is revealing additional benefits extending beyond weight loss. Whether GLP-1R agonism directly impacts brain health or does so indirectly through improved metabolic health remains to be elucidated. In exploring the intricate connection between obesity and neurological conditions, recent literature suggests that GLP-1R agonism may have the capacity to shape the neurovascular landscape. Thus, GLP-1R agonism emerges as a promising strategy for addressing the complex interplay between metabolic health and cognitive well-being.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Glp-1 ; Blood-brain Barrier ; Cerebral Blood Flow ; Cerebral Vasculature ; Cerebrospinal Fluid ; Metabolic Syndrome ; Myelination ; Neurodegeneration ; Neurovascular Coupling ; Obesity; Glucagon-like Peptide-1; Blood-brain-barrier; High-fat Diet; Focal Cerebral-ischemia; Dpp-4 Inhibitor; Hemorrhagic Transformation; Vascular-permeability; Intracranial-pressure; Cognitive Impairment; Functional Recovery
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1550-4131
e-ISSN 1932-7420
Zeitschrift Cell Metabolism
Quellenangaben Band: 36, Heft: 10, Seiten: 2173-2189 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
Förderungen National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Interstellar Initiative (NYAS/AMED)
Matilda E. Ziegler Family Foundation
McCluskey family
DOI 10.1016/j.cmet.2024.09.003
WOS ID 001390166600001
Scopus ID 85205528278
PubMed ID 39357509
Erfassungsdatum 2024-10-28
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