PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Takenaka, S. ; Möller, W. ; Semmler-Behnke, M. ; Karg, E.W. ; Wenk, A. ; Schmid, O. ; Stöger, T. ; Jennen, L. ; Aichler, M. ; Walch, A.K. ; Pokhrel, S.* ; Mädler, L.* ; Eickelberg, O. ; Kreyling, W.G.

Efficient internalization and intracellular translocation of inhaled gold nanoparticles in rat alveolar macrophages.

Nanomed. 7, 855-865 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Aim: To investigate the relationship of alveolar macrophages and inhaled nanoparticles in the lung. Materials & methods: Rats were exposed by inhalation to 14 nm gold nanoparticles for 6 hours, and ultramicroscopic observation on the frequency and localization of gold nanoparticles within lavaged macrophages was performed up to 7 days. Results & discussion: The majority of macrophages examined on day 0 (94%) contained internalized gold nanoparticles, and the percentage decreased to 59% on day 7. Gold nanoparticles were exclusively found within cytoplasmic vesicles. On day 0, most gold nanoparticles appeared to be individual or slightly agglomerated, and they were frequently agglomerated on day 7. Conclusion: Alveolar macrophages efficiently internalized nanoparticles by endocytosis, and re-arrangements of vesicles and of nanoparticles in the vesicles of macrophages occurred.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
5.055
1.033
27
28
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter nanoparticle, inhalation, gold, alveolar macrophage, internalization; cellular trafficking
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 1743-5889
e-ISSN 1748-6963
Zeitschrift Nanomedicine
Quellenangaben Band: 7, Heft: 6, Seiten: 855-865 Artikelnummer: , Supplement: ,
Verlag Future Medicine
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
Research Unit Analytical Pathology (AAP)
Institute of Pathology (PATH)
Cooperation Group Comprehensive Molecular Analytics (CMA)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies

30202 - Environmental Health
30205 - Bioengineering and Digital Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Lung Research

Enabling and Novel Technologies
PSP-Element(e) G-505000-009
G-505000-002
G-501600-001
G-505000-008
G-505000-001
G-500390-001
G-500300-001
PubMed ID 22475647
DOI 10.2217/NNM.11.152
WOS ID WOS:000305713400014
Scopus ID 84862870150
Erfassungsdatum 2012-04-04
[➜Korrektur melden]