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Bui, H.* ; Keshawarz, A.* ; Wang, M.* ; Lee, M.* ; Ratliff, S.M.* ; Lin, L.* ; Birditt, K.S.* ; Faul, J.D.* ; Peters, A. ; Gieger, C. ; Delerue, T. ; Kardia, S.L.R.* ; Zhao, W.* ; Guo, X.* ; Yao, J.* ; Rotter, J.I.* ; Li, Y.* ; Liu, X.* ; Liu, D.* ; Tavares, J.F.* ; Pehlivan, G.* ; Breteler, M.M.B.* ; Karabegović, I.* ; Ochoa-Rosales, C.* ; Voortman, T.* ; Ghanbari, M.* ; van Meurs, J.B.J.* ; Nasr, M.K.* ; Dörr, M.* ; Grabe, H.J.* ; London, S.J.* ; Teumer, A.* ; Waldenberger, M. ; Weir, D.R.* ; Smith, J.A.* ; Levy, D.* ; Ma, J.* ; Liu, C.*

Association analysis between an epigenetic alcohol risk score and blood pressure.

Clin. Epigenet. 16:149 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Epigenome-wide association studies have identified multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases. This study aimed to test the hypothesis that an alcohol consumption epigenetic risk score (ERS) is associated with blood pressure (BP) traits. RESULTS: We implemented an ERS based on a previously reported epigenetic signature of 144 alcohol-associated CpGs in meta-analysis of participants of European ancestry. We found a one-unit increment of ERS was associated with eleven drinks of alcohol consumed per day, on average, across several cohorts (p < 0.0001). We examined the association of the ERS with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (HTN) in 3,898 Framingham Heart Study (FHS) participants. Cross-sectional analyses in FHS revealed that a one-unit increment of the ERS was associated with 1.93 mm Hg higher SBP (p = 4.64E-07), 0.68 mm Hg higher DBP (p = 0.006), and an odds ratio of 1.78 for HTN (p < 2E-16). Meta-analysis of the cross-sectional association of the ERS with BP traits in eight independent external cohorts (n = 11,544) showed similar relationships with BP levels, i.e., a one-unit increase in ERS was associated with 0.74 mm Hg (p = 0.002) higher SBP and 0.50 mm Hg (p = 0.0006) higher DBP, but not with HTN. Longitudinal analyses in FHS (n = 3260) and five independent external cohorts (n = 4021) showed that the baseline ERS was not associated with a change in BP over time or with incident HTN. CONCLUSIONS: Our findings demonstrate that the ERS has potential clinical utility in assessing lifestyle factors related to cardiovascular risk, especially when self-reported behavioral data (e.g., alcohol consumption) are unreliable or unavailable.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Alcohol ; Blood Pressure ; Dna Methylation ; Epigenetic Risk Score ; Hypertension
ISSN (print) / ISBN 1868-7075
e-ISSN 1868-7083
Zeitschrift Clinical Epigenetics
Quellenangaben Band: 16, Heft: 1, Seiten: , Artikelnummer: 149 Supplement: ,
Verlag Springer
Verlagsort Berlin : Heidelberg
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)