PuSH - Publikationsserver des Helmholtz Zentrums München

Governa, V.* ; de Oliveira, K.G.* ; Bång-Rudenstam, A.* ; Offer, S. ; Cerezo-Magaña, M.* ; Li, J.* ; Beyer, S.* ; Johansson, M.C.* ; Månsson, A.S.* ; Edvardsson, C.* ; Durmo, F.* ; Gustafsson, E.* ; Boukredine, A.* ; Jeannot, P.* ; Schmidt, K.* ; Gezelius, E.* ; Menard, J.A.* ; Garza, R.* ; Jakobsson, J.* ; de Neergaard, T.* ; Sundgren, P.C.* ; Tiihonen, A.M.* ; Haapasalo, H.* ; Rautajoki, K.J.* ; Nordenfelt, P.* ; Darabi, A.* ; Forsberg-Nilsson, K.* ; Pietras, A.* ; Talbot, H.* ; Bengzon, J.* ; Belting, M.*

Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted.

Sci. Transl. Med. 16:eadk1168 (2024)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet-loaded macrophage, in human glioblastoma. Through extensive analyses of patient tumors, together with in vitro and in vivo investigations, we found that TAFs exhibit distinct protumorigenic characteristics related to hypoxia, mesenchymal transition, angiogenesis, and impaired phagocytosis, and their presence correlates with worse outcomes for patients with glioma. We further demonstrated that TAF formation is facilitated by lipid scavenging from extracellular vesicles released by glioblastoma cells. We found that targeting key enzymes involved in lipid droplet formation, such as diacylglycerol O-acyltransferase or long-chain acyl-CoA synthetase, effectively disrupted TAF functionality. Together, these data highlight TAFs as a prominent immune cell population in glioblastoma and provide insights into their contribution to the tumor microenvironment. Disrupting lipid droplet formation to target TAFs may represent an avenue for future therapeutic development for glioblastoma.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 1946-6234
e-ISSN 1946-6242
Zeitschrift Science Translational Medicine
Quellenangaben Band: 16, Heft: 771, Seiten: , Artikelnummer: eadk1168 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Cooperation Group Comprehensive Molecular Analytics (CMA)