Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
Verlagsversion
DOI
PMC
 |
Open Access Gold |
|
möglich sobald bei der ZB eingereicht worden ist.
Impacts of low birthweight on kidney development and intergenerational growth of the offspring.
iScience 27:111159 (2024)
Low birthweight (LBW) increases the risk of adult-onset diseases, including kidney diseases, with intergenerational consequences; however, the underlying mechanisms and effective interventions are unclear. To examine the cross-generational effects of LBW, we established an LBW mouse model through reduced uterine perfusion pressure (RUPP) and investigated the therapeutic potential of tadalafil, a phosphodiesterase 5 inhibitor, on LBW-associated consequences. RUPP-pups (R1) had lower fetal and birth weights, delayed renal development, and fewer glomeruli than Sham-pups. In adulthood, R1 mice exhibited persistently fewer glomeruli and elevated blood pressure, while Tadalafil-R1 mice showed reduced hypertension in both sexes and improved renal pathological changes in males. Additionally, pregnant R1 mice displayed inadequate gestational liver hypertrophy, impaired hepatic purine metabolism, and diminished placental angiogenesis, resulting in fetal growth restriction in the subsequent generation. These findings underscore the lasting impact of LBW on adult health and future generations and suggest tadalafil's potential to mitigate LBW-associated risks.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Biological Sciences ; Metabolomics ; Physiology; Glomerular Number; Nephron Number; Fetal; Preeclampsia; Tadalafil; Restriction; Risk; Pregnancy; Disease; Liver
ISSN (print) / ISBN
2589-0042
e-ISSN
2589-0042
Zeitschrift
iScience
Quellenangaben
Band: 27,
Heft: 11,
Artikelnummer: 111159
Verlag
Elsevier
Verlagsort
Amsterdam ; Bosten ; London ; New York ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Metabolism and Cell Death (MCD)
Förderungen
Laboratory Animal Pathology Platform, Common Equipment Office, Tohoku University Graduate School of Medicine
Japan Society for the Promotion of Science KAKENHI
Kawano Masanori Memorial Public Interest Incorporated Foundation
Japan Society for the Promotion of Science KAKENHI
Kawano Masanori Memorial Public Interest Incorporated Foundation